Results 51 to 60 of about 21,277,776 (188)

17. August 1956: Das KPD-Verbot und die Haltung der SPD-Fraktion

, 2018
1
Meyer-Braun, Renate
core   +1 more source

Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.

PLoS ONE, 2019
BackgroundInhibition of the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis in combination with radiotherapy may be a promising approach to treat cancer.
Tetsuro Tominaga, Takashi Akiyoshi, Noriko Yamamoto, Senzo Taguchi, Seiichi Mori, Toshiya Nagasaki, Yosuke Fukunaga, Masashi Ueno   +7 more
doaj   +1 more source

High intensity interval exercise increases the frequency of peripheral PD-1+ CD8+ central memory T-cells and soluble PD-L1 in humans

Brain, Behavior, & Immunity - Health, 2020
Exercise can exert anti-inflammatory effects in an intensity-dependent manner; however, the mechanisms mediating these effects are continually being established.
Alex J. Wadley, Tom Cullen, Jordan Vautrinot, Gary Keane, Nicolette C. Bishop, Steven J. Coles   +5 more
doaj   +1 more source

Malondialdehyde Acetaldehyde-Adduction Changes Surfactant Protein D Structure and Function

Frontiers in Immunology, 2022
Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate immunity via bacterial aggregation and lysis, as well as by enhancing macrophage ...
Claire G. Nissen, Deanna D. Mosley, Kusum K. Kharbanda, Kusum K. Kharbanda, Dawn M. Katafiasz, Kristina L. Bailey, Kristina L. Bailey, Todd A. Wyatt, Todd A. Wyatt, Todd A. Wyatt   +9 more
doaj   +1 more source

Assessing the Clinical Relevance of Soluble PD-1 and PD-L1: A Multi-Cohort Study Across Diverse Tumor Types and Prognostic Implications

Biomedicines
Background/Objectives: Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, however the clinical relevance of their soluble forms (sPD-1 and sPD-L1) remains less studied. Soluble PD-1 and PD-L1 have been
Nikolay E. Kushlinskii, Olga V. Kovaleva, Alexei N. Gratchev, Alexander A. Alferov, Yurii B. Kuzmin, Nikolai Y. Sokolov, Dmitry A. Tsekatunov, Irina B. Ryzhavskaya, Igor N. Kuznetsov, Dmitry N. Kushlinskii, Zaman Z. Mamedli, Ivan S. Stilidi   +11 more
doaj   +1 more source

High Serum Level of Soluble Programmed Death Ligand 1 is Associated With a Poor Prognosis in Hodgkin Lymphoma

Translational Oncology, 2018
Blockade of the programmed cell death 1-programmed cell death ligand 1 pathway is a new and promising therapeutic approach in Hodgkin lymphoma (HL).
Xiaofang Guo, Juan Wang, Jietian Jin, Hao Chen, Zijun Zhen, Wenqi Jiang, Tongyu Lin, Huiqiang Huang, Zhongjun Xia, Xiaofei Sun   +9 more
doaj   +1 more source

Epstein–Barr Virus LMP1 Induces Soluble PD-L1 in Nasopharyngeal Carcinoma

Microorganisms, 2021
Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated malignancy. The principal oncogene of EBV, latent membrane protein 1 (LMP1), induces the expression of programmed death-ligand 1 (PD-L1), which is an immunosuppressive transmembrane
Kina Kase, Satoru Kondo, Naohiro Wakisaka, Hirotomo Dochi, Harue Mizokami, Eiji Kobayashi, Makoto Kano, Takeshi Komori, Nobuyuki Hirai, Takayoshi Ueno, Yosuke Nakanishi, Miyako Hatano, Kazuhira Endo, Makiko Moriyama-Kita, Hisashi Sugimoto, Tomokazu Yoshizaki   +15 more
doaj   +1 more source

Prognostic significance of soluble PD-L1 in prostate cancer

Frontiers in Immunology
PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score ...
Margarita Zvirble, Margarita Zvirble, Zilvinas Survila, Paulius Bosas, Paulius Bosas, Neringa Dobrovolskiene, Agata Mlynska, Agata Mlynska, Gintaras Zaleskis, Jurgita Jursenaite, Dainius Characiejus, Dainius Characiejus, Vita Pasukoniene   +12 more
doaj   +1 more source

Supplementation of nitric oxide and spermidine alleviates the nickel stress-induced damage to growth, chlorophyll metabolism, and photosynthesis by upregulating ascorbate–glutathione and glyoxalase cycle functioning in tomato

Frontiers in Plant Science, 2022
Experiments were conducted to evaluate the role of exogenously applied nitric oxide (NO; 50 µM) and spermidine (Spd; 100 µM) in alleviating the damaging effects of Ni (1 mM NiSO46H2O) toxicity on the growth, chlorophyll metabolism, photosynthesis, and ...
Cheng Qin, Jie Shen, Mohammad Abass Ahanger   +2 more
doaj   +1 more source

Soluble immune checkpoint molecules: mechanism of formation, function, role in malignant neoplasms

Медицинская иммунология
Immune checkpoints (ICs) represent a broad set of stimulatory and inhibitory signaling pathways playing an important role in regulation of immune responses.
T. V. Glazanova, I. E. Pavlova, E. V. Kuzmich, L. N. Bubnova   +3 more
doaj   +1 more source