Results 31 to 40 of about 158,858 (186)

The correlation of serum sPD-1 and sPD-L1 levels with clinical, pathological characteristics and lymph node metastasis in nonsmall cell lung cancer patients [PDF]

Turk J Med Sci, 2022
Background/aim: Significant advances have been achieved in immunotherapy for the treatment of lung cancer. It is known that tumor cells and cells in the tumor microenvironment express high amounts of programmed cell death ligand 1 (PD-L1).
ZEYNEP SARIBAŞ, METİN DEMİRCİN, DEMİRCİN, METİN, SERKAN UYSAL, YİĞİT YILMAZ, DİKMEN, ERKAN, Yilmaz, Yigit, KUMBASAR, ULAŞ, Ozercan, Mesut Melih, BURCU ANCIN, RIZA DOĞAN, UYSAL, SERKAN, MESUT MELİH ÖZERCAN, ULAŞ KUMBASAR, DOĞAN, RIZA, SARIBAŞ, ZEYNEP, Ancin, Burcu, ERKAN DİKMEN   +17 more
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An investigation of the relationship between sPD-1, sPD-L1 and severe pneumonia patients admitted to ICU and its clinical significance [PDF]

Frontiers in Medicine
BackgroundSoluble programmed cell death 1 (sPD-1) and its ligand (sPD-L1) have emerged as potential biomarkers for early identification and risk stratification in patients with severe pneumonia (SP). However, there is a lack of robust laboratory evidence supporting their clinical utility.
Zirong Gao, Zirong Gao, Yanhui Lu, Shanshan Yu, Bao Fu   +4 more
openaire   +4 more sources

The Predictive Value of Liver/Spleen CT Value, BISAP Score Combined with Serum sPD-L1 for Hyperlipidemic Acute Pancreatitis [PDF]

International Journal of General Medicine
To explore the predictive value of liver/spleen CT Value, bedside index for severity in acute pancreatitis (BISAP) score combined with serum soluble programmed death ligand 1 (sPD-L1) within 24 hours of onset for the severity tendency of hyperlipidemic acute pancreatitis (HTG-AP).A retrospective study was conducted on the clinical data of 102 patients ...
Tao Liu, Lina Peng, Yifang Huo, Ting Lu, Xiaoping Lv   +4 more
openaire   +4 more sources

Prognostic and clinicopathological value of soluble programmed cell death ligand-1 (sPD-L1) in patients with peripheral T-cell lymphoma: a meta-analysis [PDF]

Ann Med
Background Previous studies have explored whether soluble programmed cell death ligand-1 (sPD-L1) can be used to predict the prognosis of patients with peripheral T-cell lymphoma (PTCL); however, no consistent results have been obtained. Consequently, we
Ying Wu, Yan Zhang
core   +2 more sources

Immune Checkpoint Dysregulation in Aneurysmal Subarachnoid Hemorrhage: A Prospective Study of sCTLA-4 and sPD-L1 as Biomarkers of Symptomatic Vasospasm [PDF]

International Journal of Molecular Sciences
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe stroke subtype often complicated by symptomatic cerebral vasospasm (sVP), contributing to delayed cerebral ischemia and poor outcomes. Immune dysregulation, particularly T-cell imbalances and pro-inflammatory cytokines, is implicated in vasospasm development.
Reka Varnai, Gábor J. Szebeni, Nikolett Gémes, Attila Schwarcz, Tihamer Molnar, Csaba Olah, Peter Csecsei   +6 more
openaire   +4 more sources

Serum levels of soluble programmed death-ligand 1 (sPD-L1) in patients with primary central nervous system diffuse large B-cell lymphoma [PDF]

BMC Cancer, 2020
Background The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD-L1 (sPD-L1) from PD-L1 expressing
Inju Cho, Hansang Lee, Sang Eun Yoon, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim, Seok Jin Kim   +6 more
doaj   +2 more sources

The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies [PDF]

Health Sci Rep
Background and Aims There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD‐1) and programmed death ligand 1 (sPD‐L1) have demonstrated
Zheng Li, Wenjie Mao, Xuan Li, Jie Li, Qiyao Yu, Bin Li   +5 more
core   +2 more sources

Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles

Journal for ImmunoTherapy of Cancer, 2020
Background Trans-acting programmed death-ligand 1 (PD-L1) derives from malignant cells in three known forms. High levels of secreted splice variant PD-L1 (sPD-L1), ADAM10/ADAM17-shed sPD-L1, and PD-L1-positive extracellular vesicles (evPD-L1) each ...
Haidong Dong, Svetomir N Markovic, Aaron S Mansfield, Jacob J Orme, Elizabeth Ann L Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M Harrington, Matthew K Ball, Sean S Park, Mathew S Block, Yiyi Yan, Roxana S Dronca, Jeffrey L Winters   +14 more
doaj   +2 more sources

Prognostic significance of soluble PD-L1 in prostate cancer [PDF]

Frontiers in Immunology
PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score ...
Margarita Zvirble, Margarita Zvirble, Zilvinas Survila, Paulius Bosas, Paulius Bosas, Neringa Dobrovolskiene, Agata Mlynska, Agata Mlynska, Gintaras Zaleskis, Jurgita Jursenaite, Dainius Characiejus, Dainius Characiejus, Vita Pasukoniene   +12 more
doaj   +3 more sources

Clinical significance of soluble programmed cell death ligand-1 (sPD-L1) in hepatocellular carcinoma patients treated with radiotherapy

Radiotherapy and Oncology, 2018
PURPOSE: To investigate the clinical implications of the soluble programmed cell death-ligand 1 (sPD-L1) level in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT).
김현주, 성진실
core   +4 more sources