Results 51 to 60 of about 158,858 (186)

The combination of soluble forms of PD-1 and PD-L1 as a predictive marker of PD-1 blockade in patients with advanced cancers: a multicenter retrospective study

Frontiers in Immunology, 2023
IntroductionThe clinical relevance of soluble forms of programmed cell death-1 (sPD-1) and programmed cell death-ligand 1 (sPD-L1) remains unclear. We here investigated the relation between the efficacy of PD-1 blockade and pretreatment plasma levels of ...
Takashi Kurosaki, Kenji Chamoto, Kenji Chamoto, Shinichiro Suzuki, Hiroaki Kanemura, Seiichiro Mitani, Kaoru Tanaka, Hisato Kawakami, Yo Kishimoto, Yasuharu Haku, Katsuhiro Ito, Toshiyuki Sato, Chihiro Suminaka, Mami Yamaki, Yasutaka Chiba, Tomonori Yaguchi, Tomonori Yaguchi, Koichi Omori, Takashi Kobayashi, Kazuhiko Nakagawa, Tasuku Honjo, Hidetoshi Hayashi   +21 more
doaj   +1 more source

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundSoluble programmed cell death-ligand 1 (sPD-L1) has been well documented to activate immunosuppression and is considered an essential predictor of negative clinical outcomes for several malignances and inflammatory conditions.
Shuping Li, Ling Yi, Xiqing Wei, Jinguo Zhang, Xiaojue Wang, Chang Jiang, Zhuohong Yan, Liwei Song, Bin Yang, Panjian Wei, Xiang Gao, Jinghui Wang, Hongtao Zhang, Jian Zhang   +13 more
doaj   +1 more source

Table_1_The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas.DOCX

, 2020
Background: Soluble PD-L1 (sPD-L1) in the circulation has been documented to activate global immunosuppression and is considered a predictor of negative clinical outcomes in several malignances.
Yadi Zhu (8347542), Bo Sun (177052), Shujun Liu (28553), Xixiong Kang (157578), Chenxi Zhang (1498195), Guojun Zhang (157554), Yubo Fan (301788), Xiangrui Meng (3566795)   +7 more
core   +1 more source

High Pretreatment Serum PD-L1 Levels Are Associated with Muscle Invasion and Shorter Survival in Upper Tract Urothelial Carcinoma

Biomedicines, 2022
Programmed death ligand-1 (PD-L1) is an immune checkpoint molecule and a widely used therapeutic target in urothelial cancer. Its circulating, soluble levels (sPD-L1) were recently suggested to be associated with the presence and prognosis of various ...
Ádám Széles, Petra Terézia Kovács, Anita Csizmarik, Melinda Váradi, Péter Riesz, Tamás Fazekas, Szilárd Váncsa, Péter Hegyi, Csilla Oláh, Stephan Tschirdewahn, Christopher Darr, Ulrich Krafft, Viktor Grünwald, Boris Hadaschik, Orsolya Horváth, Péter Nyirády, Tibor Szarvas   +16 more
doaj   +1 more source

High Serum Level of Soluble Programmed Death Ligand 1 is Associated With a Poor Prognosis in Hodgkin Lymphoma

Translational Oncology, 2018
Blockade of the programmed cell death 1-programmed cell death ligand 1 pathway is a new and promising therapeutic approach in Hodgkin lymphoma (HL).
Xiaofang Guo, Juan Wang, Jietian Jin, Hao Chen, Zijun Zhen, Wenqi Jiang, Tongyu Lin, Huiqiang Huang, Zhongjun Xia, Xiaofei Sun   +9 more
doaj   +1 more source

Expression of sPD-L1 levels in an ex vivo liver perfusion model

Clinical and Experimental Immunology
Abstract The programmed cell death protein 1 (PD-1) acts as a central inhibitory immune checkpoint receptor. The soluble form of its primary ligand, sPD-L1, was found to be elevated in the serum of patients with cancer, infectious diseases, and chronic inflammation.
Christian Irsara, Annemarie Weissenbacher, Felix Julius Krendl, Markus Anliker, Julia Hofmann, Theresa Hautz, Stefan Schneeberger, Andrea Griesmacher, Lorin Loacker   +8 more
openaire   +2 more sources

Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer

Frontiers in Immunology, 2022
The immune checkpoint pathway consisting of the cell membrane-bound molecule programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate negative regulatory signals that effectively inhibit T-cell proliferation and function and ...
Mengke Niu, Yiming Liu, Ming Yi, Dechao Jiao, Kongming Wu, Kongming Wu   +5 more
doaj   +1 more source

Smoking Is Associated With Low Levels of Soluble PD-L1 in Rheumatoid Arthritis

Frontiers in Immunology, 2018
BackgroundSmoking is a risk factor for developing rheumatoid arthritis (RA), but the mechanism remains uncertain. We previously demonstrated that smoking lowers the T cell activation threshold by limiting programmed death protein 1 (PD-1) expression ...
Caroline Wasén, Malin C. Erlandsson, Apostolos Bossios, Linda Ekerljung, Carina Malmhäll, Sofia Töyrä Silfverswärd, Rille Pullerits, Rille Pullerits, Bo Lundbäck, Maria I. Bokarewa   +9 more
doaj   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

The predictive role of soluble programmed death ligand 1 in digestive system cancers

Frontiers in Oncology, 2023
IntroductionThe prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.MethodsComprehensive searches were run on
Jian Ruan, Zhihong Zhao, Yuting Qian, Ruilian Xu, Guixiang Liao, Feng-Ming (Spring) Kong, Feng-Ming (Spring) Kong   +6 more
doaj   +1 more source