Results 61 to 70 of about 158,858 (186)

Tumor‐Derived Extracellular Vesicles in Plasma for Predicting Anti‐PD‐1 Antibody Efficacy in Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
New antibody‐based sandwich assays to measure plasma extracellular vesicle (EV) subsets derived from tumor tissues were developed. These EVs can be easily measured repeatedly at appropriate times. They may be useful as liquid biopsies for early cancer detection and for predicting efficacy following surgery and anti‐PD‐1 antibody in NSCLC patients ...
Tomonari Kinoshita, Shigeki Ohta, Seiki Wakui, Chihaya Maeda, Yuichiro Hayashi, Aya Misawa, Ryosuke Satomi, Shinnosuke Ikemura, Kenzo Soejima, Tomonori Yaguchi, Shotaro Maruyama, Hiroshi Kagamu, Yutaka Kawakami   +12 more
wiley   +1 more source

Soluble PD-L1 is associated with local and systemic inflammation markers in primary and secondary brain tumours

ESMO Open, 2020
Background Immune-modulatory treatments have so far shown limited clinical activity in primary brain tumours. We aimed to investigate soluble programmed death receptor ligand 1 (sPD-L1) as systemic inflammation parameter in patients with brain tumour ...
Maximilian J Mair, Sahra Pajenda, Barbara Kiesel, Georg Widhalm, Karin Dieckmann, Katharina Feldmann, Johannes Hainfellner, Ludwig Wagner   +7 more
doaj   +1 more source

From Tumour to Bloodstream: Advancing PD‐L1 Testing With Liquid Biopsies in Non‐Small Cell Lung Cancer

Cytopathology, EarlyView.
This review explores liquid biopsy as a complementary approach to tissue‐based PD‐L1 assessment in advanced NSCLC treated with immune checkpoint inhibitors. Focusing on circulating tumour cells, extracellular vesicles, and circulating tumour DNA, it summarises current evidence, technical challenges, and future perspectives for personalised ...
R. Leporati, V. Callegari, A. Ancora, M. Palmieri, B. Riccò, E. Cabitza, L. Trudu, K. Di Emidio, C. Chiavelli, A. Eccher, I. Mastrolia, V. Catani, S. Bettelli, G. Guaitoli, M. Dominici, F. Bertolini   +15 more
wiley   +1 more source

Exploring natural sunscreens: UVB protection and antioxidant properties in gadusol‐rich fish roes extracts

Photochemistry and Photobiology, EarlyView.
Gadusol‐rich extracts provide effective UVB protection and antioxidant activity in HaCaT cells and C. elegans, highlighting their potential as natural photochemoprotective agents for pharmaceutical and cosmetic applications. It also demonstrates remarkable in vitro antioxidant capacity and thermal stability over time.
Rocío Isla Naveira, Gabriela Hollmann, José María Monserrat, Ana Paula S. Votto, Julie Medeiros da Silveira, Andressa Mai Matsumoto, Lais Zortéa, Andy Joel Taipe Huisa, Agueda E. Massa, M. Sandra Churio   +9 more
wiley   +1 more source

Soluble PD-L1 Expression After Intravenous Treatment of Cancer Patients With Selenite in Phase I Clinical Trial

Frontiers in Oncology, 2022
A high expression level of programmed death-ligand 1 (PD-L1) is observed in different types of cancers (particularly lung cancer). Soluble (s)PD-L1 may be used as a prognostic marker and a target for anti-cancer immunity, as well as, predicting gene ...
Ali Razaghi, Ladan Mansouri, Ola Brodin, Ola Brodin, Mikael Björnstedt, Joachim Lundahl   +5 more
doaj   +1 more source

Image_1_Soluble Programmed Death Receptor Ligands sPD-L1 and sPD-L2 as Liquid Biopsy Markers for Prognosis and Platinum Response in Epithelial Ovarian Cancer.TIF

, 2019
Introduction: Response to platinum-based therapy is a major prognostic factor in epithelial ovarian cancer (EOC) and reliable prognostic biomarkers are urgently needed to identify patients at high risk.
Vera Rebmann (477041), Sabine Kasimir-Bauer (3580967), Esther Schwich (5181758), Peter A. Horn (7497131), Paul Buderath (560824), Rainer Kimmig (58539), Christina Jensen (2242411)   +6 more
core   +1 more source

Plasma sPD-L1 and VEGF levels are associated with the prognosis of NSCLC patients treated with combination immunotherapy

Anti-Cancer Drugs
The clinical significance of plasma soluble programmed cell death ligand 1 (sPD-L1) and vascular endothelial growth factor (VEGF) for non-small cell lung cancer (NSCLC) treated with the combination of anti-angiogenic therapy and anti-PD-L1 antibody (Ab) remain unknown.
Changhong, Dong, Kaiyuan, Hui, Jie, Gu, Mei, Wang, Chenxi, Hu, Xiaodong, Jiang   +5 more
openaire   +2 more sources

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]

, 2013
Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
Ivics, Z., Zsuzsanna Izsvák, Lajos Mates, Ivics, Zoltán, Izsvák, Zsuzsanna, Martin, Sandra L., Xie, Y., An, Wenfeng, Mátés, Lajos, Xie, Yi, Yi Xie, Sandra L Martin, An, W., Mates, L., Martin, S.L., Izsvák, Z., Wenfeng An, Zoltán Ivics   +17 more
core   +1 more source

Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.

PLoS ONE, 2019
BackgroundInhibition of the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis in combination with radiotherapy may be a promising approach to treat cancer.
Tetsuro Tominaga, Takashi Akiyoshi, Noriko Yamamoto, Senzo Taguchi, Seiichi Mori, Toshiya Nagasaki, Yosuke Fukunaga, Masashi Ueno   +7 more
doaj   +1 more source

Accuracy of Allplex HPV HR Detection Full Genotyping Assay on Cervical Samples Compared to Vaginal Self‐Samples

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Vaginal self‐sampling is increasingly integrated into cervical cancer screening programs, requiring evidence of accurate HPV testing on self‐collected samples. This study evaluated the clinical accuracy of Allplex HPV HR Detection (Allplex) within VALHUDES, a framework established to assess the clinical performance of HPV assays on self ...
Ardashel Latsuzbaia, Severien Van Keer, Davy Vanden Broeck, Steven Weyers, Gilbert Donders, Philippe De Sutter, Wiebren Tjalma, Jean Doyen, Alex Vorsters, Marc Arbyn   +9 more
wiley   +1 more source