Results 81 to 90 of about 158,858 (186)

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source

Soluble programmed cell death ligand-1 as a predictive biomarker for severity and poor prognosis in pulmonary tuberculosis

Annals of Medicine
Background We aimed to assess whether soluble programmed death-ligand 1 (sPD-L1) could serve as a new biomarker for PTB.Methods Plasma sPD-L1 levels in the discovery cohort were analyzed through flow cytometry and validated by sandwich ELISA.
Xiaojue Wang, Weibing Lin, Huimin Li, Sibo Long, Jun Yan, Yiheng Shi, Hongtao Zhang, Xinting Yang, Ling Yi, Guirong Wang   +9 more
doaj   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Image_1_The interaction between the soluble programmed death ligand-1 (sPD-L1) and PD-1+ regulator B cells mediates immunosuppression in triple-negative breast cancer.jpeg

, 2022
Accumulating evidence suggests that regulatory B cells (Bregs) play important roles in inhibiting the immune response in tumors. Programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) are important molecules that maintain the balance of the ...
Sining Wang (8145588), Fang Xie (103933), Huan Du (3108267), Qin Wang (109812), Wenting Liu (412341), Yang Yang (45629), Shenghua Zhan (6633788), Longxiang PuYang (13136538), Qiuxia Qu (13136541), Xuejiao Li (1524745), Yuqiu Wan (2186284), Zhangyu Wang (12459888), Jing Lan (1699462)   +12 more
core   +1 more source

Soluble programmed death ligand 1 as prognostic biomarker in non-small cell lung cancer patients receiving nivolumab, pembrolizumab or atezolizumab therapy

Scientific Reports
Many studies have focused on the prognostic role of soluble programmed death ligand 1 (sPD-L1) in non-small cell lung cancer (NSCLC), but outcomes are ambiguous and further investigations are needed. We addressed the matter by studying sPD-L1 in baseline
Sinne Søberg Brun, Torben Frøstrup Hansen, Sara Witting Christensen Wen, Christa Haugaard Nyhus, Lisbeth Bertelsen, Anders Jakobsen, Torben Schjødt Hansen, Line Nederby   +7 more
doaj   +1 more source

Erken Evre Küçük Hücreli Dışı Akciğer Kanseri Hastalarında Serum sPD-1 ve sPD-L1 Düzeylerinin Klinik, Patolojik Özellikler Ve Lenf Nodu Metastazı İle Korelasyonu

, 2020
Cancer is an important health issue, with rapidly increasing incidence and mortality worldwide. Significant advances have been achieved in cancer immunotherapy with the discovery of antigens that enable cancer cells to be recognized by the immune system ...
Ancın, Burcu
core  

Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1

Journal of Translational Medicine, 2020
Background Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist.
Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło, Jan Kotarski   +8 more
doaj   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

SPD-rsfMRI-NEU-ZS.zip

, 2018
We have MRI images of 18 Schizotypal Personality Disorder (SPD) and 18 healthy controls.
Shouliang Qi (5510786)
core   +1 more source

Human‐Interpretable SEP Event Prediction Using White‐Box Explainable AI

Space Weather, Volume 24, Issue 4, April 2026.
Abstract Solar energetic particle (SEP) events pose radiation risks to astronauts and space systems, making their prediction essential. Although various prediction models have been developed, most machine learning (ML)‐based models lack interpretability; that is, it is difficult to explain the reasons behind individual predictions.
Naho Fujita, Yuta Kato, Kanya Kusano, Takashi Yanase, Chihiro Mitsuda   +4 more
wiley   +1 more source