Results 81 to 90 of about 4,694,133 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Special needs [PDF]

Nature, 1989
Ann Cowper, Cyril Young
openaire   +2 more sources

The Effect of Behavioral Management and Social Skills Training Program on Behavioral and Adaptive Problems of Male Adolescents with High-Functioning Autism

Journal of Rehabilitation, 2019
Objective: The puberty and adolescence period is very important for adolescents with High-Functioning Autism (HFA). They require more education than their peers to understand the puberty period and the its associated changes.
Leila Akrami, Malekpur Mokhtar, Salar Faramarzi, Ahmad Abedi   +3 more
doaj  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Re-Turning to Recognition and the Ongoing Search for Creative-Relational Belonging: A Collective Biography of Living with Disability

Disabilities
We, five co-authors of this paper, came together for a three-day collective biography workshop to reflect on moments of recognition that have impacted our lives.
Elisabeth De Schauwer, Jentel Van Havermaet, Inge G. E. Blockmans, Hanne Hellin, Bronwyn Davies   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transitions to and within adulthood for young people with special educational needs [PDF]

, 2016
No abstract ...
Pirrie, Anne, Rydzewska, Ewelina
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Teachers’ Attitude towards Corporal Punishment: Elementary Schools of the Central Zone of Tigray Region in Ethiopia in Focus

Ethiopian Journal of the Social Sciences and Humanities, 2014
Despite the plethora of policy and legal instruments banning corporal punishment (CP) in schools and the sea of knowledge about the negative consequences of CP in children, CP occupies a significant place in the scheme of affairs of schools across the ...
Fiseha Teklu, R. Sreevalasa Kumar
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source