Results 51 to 60 of about 801,111 (297)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effectiveness of Acceptance and Commitment Therapy on Improving Academic Self-regulation and Psychological Flexibility in Students with Specific Learning Disorder(SLD)

مطالعات روانشناختی, 2021
The purpose of this study was to evaluate The effectiveness of acceptance and commitment therapy (ACT) on improving academic self-regulation and psychological flexibility in students with specific learning disorder.
Ali Rezaeisharif, Nasser Sobhi-gharamaleki, Saeed Pourabdol , Majid Zarghamhajebi, Mahdi Beyki   +4 more
doaj   +1 more source

A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]

, 2017
INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M, Hofmann SG, Jasper Smits, Joshua Curtiss, Leigh Andrews, Lipsey MW, Michelle Davis, Stefan G. Hofmann, Stein MB   +8 more
core   +2 more sources

Specific learning disorders in epileptic children. [PDF]

Journal of Bioscience and Applied Research, 2016
Specific learning disorders are more common in epileptic children even with normal IQ, The Epilepsy related factors such as (duration of illness , type and severity of epilepsy and medications used ) are strongly related to increase risk of learning disorders.
Shewikar T. El-Bakry, Shaza M. Eltaher, Abo Zaid A. Khodair, Khaled S. Meselhey   +3 more
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comorbidities Between Specific Learning Disorders and Psychopathology in Elementary School Children in Germany

Frontiers in Psychiatry, 2020
Children with reading and/or spelling disorders have increased rates of behavioral and emotional problems and combinations of these. Some studies also find increased rates of attention-deficit/hyperactivity disorder (ADHD), conduct disorder, anxiety ...
Linda Visser, Linda Visser, Julia Kalmar, Julia Kalmar, Janosch Linkersdörfer, Janosch Linkersdörfer, Ruth Görgen, Josefine Rothe, Josefine Rothe, Marcus Hasselhorn, Marcus Hasselhorn, Gerd Schulte-Körne   +11 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in The Prefrontal Cortex Modulates Cued Fear Learning, But Not Spatial Working Memory, in Female Rats [PDF]

, 2018
A genetic polymorphism within the gene encoding the pituitary adenylate cyclase- activating polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper-reactivity to threat-related cues in women, but not men, with post-traumatic ...
Gilmartin, Marieke R., Herbst, Matthew R., Kirry, Adam J., Maskeri, Michelle M., Poirier, Sarah E., Rothwell, Amy C., Twining, Robert C.   +6 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Specific Learning Disorders (SLD) and Behavior Impairment: Comorbidity or Specific Profile?

Children, 2023
Introduction: Specific Learning Disorder (SLD) is a neurodevelopmental disorder characterized by difficulties in perceiving and processing verbal and non-verbal information. It is usually accompanied by impaired academic skills leading to school dropout and emotional disturbances, resulting in significant distress and behavioral problems.
Chieffo D. P. R., Arcangeli V., Moriconi F., Marfoli A., Lino F., Vannuccini S., Marconi E., Turrini I., Brogna C., Veredice C., Antonietti A., Sani G., Mercuri E. M.   +12 more
openaire   +3 more sources