Results 61 to 70 of about 801,111 (297)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Impaired contextual modulation of memories in PTSD: an fMRI and psychophysiological study of extinction retention and fear renewal [PDF]

, 2014
Post-traumatic stress disorder (PTSD) patients display pervasive fear memories, expressed indiscriminately. Proposed mechanisms include enhanced fear learning and impaired extinction or extinction recall. Documented extinction recall deficits and failure
Abelson, James L, Gaines, Laura M, Garfinkel, Sarah N, King, Anthony P, Liberzon, Israel, Sripada, Rebecca K, Wang, Xin   +6 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparing the effectiveness of cognitive rehabilitation and cognitive therapy based on mindfulness on improving the selective attention of students with specific learning disorders [PDF]

مجله علوم روانشناختی, 2023
Background: Learning disabilities are considered the main cause of poor academic performance, and every year a significant number of students face difficulties in learning academic subjects due to this reason.
Maryam Mohammadlou, Nemat Sotoude Asl, Raheb Ghorbani3, Siavash Talepasand   +3 more
doaj  

Investigating the prevalence and comorbidity of attention deficit hyperactivity disorder and developmental dyslexia in learners in a South African practice

South African Journal of Childhood Education, 2022
Background: Dyslexia and attention deficit hyperactivity disorder (ADHD) are marked comorbid neurodevelopmental disorders with an estimated bidirectional comorbidity of 25% – 40%.
Sandra Stark, Salomé Geertsema, Mia Le Roux, Elizabeth Bothma   +3 more
doaj   +1 more source

DISTANCE LEARNING AND SPECIFIC LEARNING DISORDERS: A UNIVERSITY DIMENSION

Giornale Italiano di Educazione alla Salute, Sport e Didattica Inclusiva, 2021
This work aims to analyze and observe the world of Specific Learning Disorders (SLDs) within the context of Distance Learning (DL), by introducing and including all the components, expressions and even the consequences that impact on the individual, projected into this different educational dimension.
A. Ascione, V. Molisso
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The Effectiveness of Assertiveness Training on Anxiety Symptoms in School-Age Children With Specific Learning Disorder

Journal of Rehabilitation, 2021
Objective: Specific learning disorder is a type of neurodevelopmental disorder, in which children with disabilities have difficulty understanding, or using spoken and written language.
Mehdi Mohagheghi, Masoumeh Pourmohamadreza-Tajrishi, Soheila Shahshahanipour, Gita Movallali, Mohsen Vahedi   +4 more
doaj  

Positive Psychology Constructs in Specific Learning Disorder: A Systematic Review Study [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī
Specific learning disability is neurodevelopmental disorder that was considered from positive psychology approach in recent years. The aim of the current research was to draw concept map of positive psychology constructs in specific learning disability ...
shahrooz nemati, rahim badri, shahram ,vahedi, Niloufar Broumandzadeh   +3 more
doaj   +1 more source