Results 171 to 180 of about 5,924,760 (360)

Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy. [PDF]

Neurobiol Stress, 2021
Reagan LP, Cowan HB, Woodruff JL, Piroli GG, Erichsen JM, Evans AN, Burzynski HE, Maxwell ND, Loyo-Rosado FZ, Macht VA, Grillo CA.   +10 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Illuminating Glucose: How to Unveil Organ-Specific Insulin Resistance and Guide Metabolic Strategies in Diabetes. [PDF]

Diabetes Metab Res Rev
Gugliandolo S, Morciano C, Leccisotti L, Capece U, Giuseppe GD, Mezza T, Ciccarelli G, Soldovieri L, Brunetti M, Avolio A, Splendore A, Pontecorvi A, Giaccari A, Cinti F.   +13 more
europepmc   +1 more source

Effects of Sub-Minimum Inhibitory Concentrations of Imipenem and Colistin on Expression of Biofilm-Specific Antibiotic Resistance and Virulence Genes in Acinetobacter baumannii Sequence Type 1894. [PDF]

Int J Mol Sci, 2022
Shenkutie AM, Zhang J, Yao M, Asrat D, Chow FWN, Leung PHM.   +5 more
europepmc   +1 more source

A new vertical power MOSFET with extremely reduced on resistance and high switching speed with multilayer structure

, 2001
A vertical power MOSFET’s whose n-drift region is stacked by alternate pn structure named as MULTILAYER POWER MOSFET has been proposed for high voltage application with extremely low on-resistance.
Hakim, M.M.A., Alam, A.H.M. Zahirul
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Pathotype-specific antimicrobial resistance in diarrheagenic <i>Escherichia coli</i>: gene variants, resistance mechanisms, and evolution of treatment strategies. [PDF]

Front Microbiol
Kamal Raj D, Saravanan SK, Viswanathan A, Elavarasu SM, Nanda Kumar SK, Sridharan KS, Govindarajan A, Krishnan S, Ramasamy M.   +8 more
europepmc   +1 more source

Genome-Wide Evolutionary Analysis of Putative Non-Specific Herbicide Resistance Genes and Compilation of Core Promoters between Monocots and Dicots. [PDF]

Genes (Basel), 2022
Chandra S, Leon RG.
europepmc   +1 more source

Progress towards implementation of a public health action plan to combat antimicrobial resistance

Since 2002, the Interagency Task Force on Antimicrobial Resistance has released an annual report on the progress towards implementation of the 2001 Action Plan to Combat Antimicrobial Resistance.

core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source