Results 181 to 190 of about 5,924,760 (360)

Characterization of tomato genes for resistance to Oidium neolycopersici

open access: yes, 2011
Tomato, Solanum lycopersicum, is a host for Oidium neolycopersici, the cause of powdery mildew (PM). Though cultivated tomatoes are susceptible to PM, resistance is reported in wild Solanum species. By screening wild tomato species, nine loci conferring
Seifi Abdolabad, A.R.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Serovar-Specific Antimicrobial Resistance and Virulence Profiles of Salmonella enterica From Poultry in Bangladesh. [PDF]

open access: yesMicrobiologyopen
Popy NN   +7 more
europepmc   +1 more source

Fusarium oxysporum f. sp. dianthi transformed with marker genes as a tool for studying resistance in Dianthus

open access: yes, 2006
Fusarium oxysporum Schlechtend:Fr. f. sp. dianthi (Prill. & Delacr.) W. C. Snyd. & H. N. Hans. (Fod), the causal agent of a vascular disease known as Fusarium wilt, represents the most important pathogen of carnation (Dianthus caryophyllus L.), causing ...
N. FALASCHI   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy