Results 181 to 190 of about 72,291,708 (309)

Experimental evolution of herbicide resistance in chlamydomonas reinhardtii [PDF]

Our understanding of the evolutionary dynamics of selection for herbicide resistance is limited by the time and space required to conduct meaningful selection experiments in higher plants. This constrains the study of the
Lagator, Mato
core  

Serovar-Specific Antimicrobial Resistance and Virulence Profiles of Salmonella enterica From Poultry in Bangladesh. [PDF]

Microbiologyopen
Popy NN, Khan MFR, Islam MS, Biswas L, Yasmin L, Siddique MP, Rahman M, Rahman MB.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Uncovering species- and drug-class-specific antimicrobial resistance mechanisms from large-scale whole-genome sequencing data using discordance analysis and machine learning. [PDF]

Brief Bioinform
Cheon NJ, Cuong Nguyen X, Unno T.
europepmc   +1 more source

Multiplex PCR assay for the simultaneous identification of race specific and non-specific leaf resistance genes in wheat (Triticum aestivum L.). [PDF]

J Appl Genet, 2023
Noweiska A, Bobrowska R, Spychała J, Tomkowiak A, Kwiatek MT.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Progress towards implementation of a public health action plan to combat antimicrobial resistance

Since 2002, the Interagency Task Force on Antimicrobial Resistance has released an annual report on the progress towards implementation of the 2001 Action Plan to Combat Antimicrobial Resistance.

core  

Pathotype-specific antimicrobial resistance in diarrheagenic <i>Escherichia coli</i>: gene variants, resistance mechanisms, and evolution of treatment strategies. [PDF]

Front Microbiol
Kamal Raj D, Saravanan SK, Viswanathan A, Elavarasu SM, Nanda Kumar SK, Sridharan KS, Govindarajan A, Krishnan S, Ramasamy M.   +8 more
europepmc   +1 more source

Postulation of Specific Disease Resistance Genes in Cereals: A Widely Used Method and Its Detailed Description. [PDF]

Pathogens, 2022
Dreiseitl A.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source