Results 1 to 10 of about 51,197 (224)

Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity

Scientific Reports, 2021
The neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational modifications impinge on spectrin, the major component of the MPS, but their role remains poorly ...
Arkadiusz Miazek, Michał Zalas, Joanna Skrzymowska, Bryan A. Bogin, Krzysztof Grzymajło, Tomasz M. Goszczynski, Zachary A. Levine, Jon S. Morrow, Michael C. Stankewich   +8 more
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β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

eLife, 2020
Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS ...
Cheng-Hsin Liu, Ryan Seo, Tammy Szu-Yu Ho, Michael Stankewich, Peter J Mohler, Thomas J Hund, Jeffrey L Noebels, Matthew N Rasband   +7 more
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Spectrin-based membrane skeleton supports ciliogenesis.

PLoS Biology, 2019
Cilia are remarkable cellular devices that power cell motility and transduce extracellular signals. To assemble a cilium, a cylindrical array of 9 doublet microtubules push out an extension of the plasma membrane.
Ru Jia, Dongdong Li, Ming Li, Yongping Chai, Yufan Liu, Zhongyun Xie, Wenxin Shao, Chao Xie, Liuju Li, Xiaoshuai Huang, Liangyi Chen, Wei Li, Guangshuo Ou   +12 more
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Glial βii spectrin contributes to paranode formation and maintenance [PDF]

Journal of Neuroscience, 2018
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D., Chang, Kae Jiun, Dupree, Jeffrey L., Galiano, Mauricio Raul, Griggs, Ryan B., Huang, Claire Yu Mei, Liu, Yanhong, Rasband, Matthew N., Susuki, Keiichiro, Tsai, Chang Ru, Yermakov, Leonid M., Zhang, Chuansheng, Zollinger, Daniel R.   +12 more
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αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation? [PDF]

PLoS ONE, 2017
T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation.
Justyna M Meissner, Aleksander F Sikorski, Tomasz Nawara, Jakub Grzesiak, Krzysztof Marycz, Dżamila M Bogusławska, Izabela Michalczyk, Marie-Christine Lecomte, Beata Machnicka   +8 more
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Shigella flexneri utilize the spectrin cytoskeleton during invasion and comet tail generation [PDF]

BMC Microbiology, 2012
Background The spectrin cytoskeleton is emerging as an important host cell target of enteric bacterial pathogens. Recent studies have identified a crucial role for spectrin and its associated proteins during key pathogenic processes of Listeria ...
Ruetz Tyson J, Lin Ann E, Guttman Julian A   +2 more
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Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age

Cellular Physiology and Biochemistry, 2017
Background: Old human red blood cells (RBCs) have a reduced surface area with respect to young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin-free vesicles that are shed in vitro under different experimental ...
Annarita Ciana, Cesare Achilli, Giampaolo Minetti   +2 more
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The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. [PDF]

PLoS Computational Biology, 2015
The primary, secondary, and tertiary structures of spectrin are reasonably well defined, but the structural basis for the known dramatic molecular shape change, whereby the molecular length can increase three-fold, is not understood.
Jeffrey W Brown, Esther Bullitt, Sira Sriswasdi, Sandra Harper, David W Speicher, C James McKnight   +5 more
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Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.

PLoS Pathogens, 2017
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P.
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis   +6 more
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Dysfunction in the βII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia. [PDF]

Circulation, 2015
Background: The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked with cardiac pathologies including myopathies ...
Bhakta, Deepak, Binkley, Philip F., Bonilla, Ingrid M., Carnes, Cynthia A., Curran, Jerry, Dobrev, Dobromir, Higgins, Robert S., Hughes, Langston D., Hund, Thomas J., Janssen, Paul M., Kilic, Ahmet, Kline, Crystal F., Little, Sean C., Long, Victor P., Ma, Jianjie, Makara, Michael, Mohler, Peter J., Polina, Iuliia, Rasband, Matthew N., Smith, Sakima A., Spoonamore, Katherine G., Sturm, Amy C., Sun, Mingzhai, Vatta, Matteo, Voigt, Niels, Webb, Tyler R., Wei, Zhiyi, Weiss, Raul, Wright, Patrick, Zhang, Chuansheng, Zhang, Mingjie   +30 more
core   +2 more sources