Non-Synaptic Function and Localization of Syntaxin-Binding Protein 1 in a Mouse Model of STXBP1-Related Epileptic Encephalopathy. [PDF]
Ann NeurolObjective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Yang T +10 more
europepmc +2 more sources
Crossed Erythrocytes Agglutination Pattern Observed in a Patient With Hereditary Elliptocytosis. [PDF]
Int J Lab HematolInternational Journal of Laboratory Hematology, Volume 48, Issue 2, Page 240-241, April 2026.
Melo MAW +3 more
europepmc +2 more sources
Characterization of Spectrin Family Genes and Their Evolutionary Roles in Domestication and Breeding of the Silkworm <i>Bombyx mori</i>. [PDF]
InsectsLu K +9 more
europepmc +3 more sources
The spectrin cytoskeleton is crucial for adherent and invasive bacterial pathogenesis. [PDF]
PLoS ONE, 2011 Various enteric bacterial pathogens target the host cell cytoskeletal machinery as a crucial event in their pathogenesis. Despite thorough studies detailing strategies microbes use to exploit these components of the host cell, the role of the spectrin ...
Tyson Ruetz +2 more
doaj +1 more source
Frontiers in Neurology, 2021 ßIV-spectrin is a protein of the spectrin family which is involved in the organization of the cytoskeleton structure and is found in high quantity in the axon initial segment and the nodes of Ranvier.
Aziza Miriam Belkheir +9 more
doaj +1 more source
β spectrin-dependent and domain specific mechanisms for Na+ channel clustering
eLife, 2020 Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS ...
Cheng-Hsin Liu +7 more
doaj +1 more source
318 Building A Better CAR: Improving CAR-T Trafficking in Cancer Therapy
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: #NAME? METHODS/STUDY POPULATION: Cell culture & protein identification: human T cells were purified from healthy blood, then activated & cultured for 5d. CAR-T cells were collected from infusion bags of cancer patients undergoing CAR-T.
Yeonsun Hong +16 more
doaj +1 more source
αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation? [PDF]
PLoS ONE, 2017 T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation.
Justyna M Meissner +8 more
doaj +1 more source
β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Scientific Reports, 2022 Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem ...
Sarah A. Denha +3 more
doaj +1 more source
American Journal of Clinical Pathology, 2011 Abstract Spectrins are large, rod-like, multifunctional molecules that participate in maintaining cell structure, signal transmission, and DNA repair. Because little is known about the role of spectrins in normal hematopoiesis and leukemogenesis, we immunohistochemically stained bone marrow biopsy specimens from 81 patients for αI, αII ...
Lucia R. Wolgast +10 more
openaire +1 more source