Results 21 to 30 of about 51,266 (290)
Competition between myosin II and βH-spectrin regulates cytoskeletal tension
eLife, 2023 Spectrins are membrane cytoskeletal proteins generally thought to function as heterotetramers comprising two α-spectrins and two β-spectrins. They influence cell shape and Hippo signaling, but the mechanism by which they influence Hippo signaling has ...
Consuelo Ibar +3 more
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Ankyrin-R Links Kv3.3 to the Spectrin Cytoskeleton and Is Required for Purkinje Neuron Survival
Journal of Neuroscience, 2021 Ankyrin scaffolding proteins are critical for membrane domain organization and protein stabilization in many different cell types including neurons. In the cerebellum, Ankyrin-R (AnkR) is highly enriched in Purkinje neurons, granule cells, and in the ...
Sharon R. Stevens +5 more
semanticscholar +1 more source
Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis. [PDF]
PLoS ONE, 2011 Using a lectin, Achatinin-H, having preferential specificity for glycoproteins with terminal 9-O-acetyl sialic acid derivatives linked in α2-6 linkages to subterminal N-acetylgalactosamine, eight distinct disease-associated 9-O-acetylated ...
Sajal Samanta +10 more
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The spectrin cytoskeleton is crucial for adherent and invasive bacterial pathogenesis. [PDF]
PLoS ONE, 2011 Various enteric bacterial pathogens target the host cell cytoskeletal machinery as a crucial event in their pathogenesis. Despite thorough studies detailing strategies microbes use to exploit these components of the host cell, the role of the spectrin ...
Tyson Ruetz +2 more
doaj +1 more source
Frontiers in Neurology, 2021 ßIV-spectrin is a protein of the spectrin family which is involved in the organization of the cytoskeleton structure and is found in high quantity in the axon initial segment and the nodes of Ranvier.
Aziza Miriam Belkheir +9 more
doaj +1 more source
318 Building A Better CAR: Improving CAR-T Trafficking in Cancer Therapy
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: #NAME? METHODS/STUDY POPULATION: Cell culture & protein identification: human T cells were purified from healthy blood, then activated & cultured for 5d. CAR-T cells were collected from infusion bags of cancer patients undergoing CAR-T.
Yeonsun Hong +16 more
doaj +1 more source
β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Scientific Reports, 2022 Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem ...
Sarah A. Denha +3 more
doaj +1 more source
Molecular consequences of SCA5 mutations in the spectrin-repeat domains of β-III-spectrin. [PDF]
J Biol ChemDenha SA +7 more
europepmc +3 more sources
Posttranslational control of membrane-skeleton (ankyrin and alpha beta- spectrin) assembly in early myogenesis [PDF]
, 1985 Adult chicken skeletal muscle cells express polypeptides that are antigenically related to alpha-spectrin (Mr 240,000) and beta-spectrin (Mr 220,000-225,000), the major components of the erythrocyte membrane- skeleton, and to ankyrin (Mr 237,000; also ...
Lazarides, Elias, Nelson, W. James
core +1 more source