Results 81 to 90 of about 51,266 (290)

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

A lymphoma plasma membrane-associated protein with ankyrin-like properties. [PDF]

, 1986
In this study we have used several complementary techniques to isolate and characterize a 72-kD polypeptide that is tightly associated with a major mouse T-lymphoma membrane glycoprotein, gp 85 (a wheat germ agglutinin-binding protein), in a 16 S complex.
Balazovich, K, Bourguignon, LY, Suchard, SJ, Walker, G   +3 more
core  

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Biogenesis of the Avian Erythroid Membrane Skeleton : Receptor-mediated Assembly and Stabilization of Ankyrin (Goblin) and Spectrin [PDF]

, 1984
Ankyrin is an extrinsic membrane protein in human erythrocytes that links the αß-spectrin-based extrinsic membrane skeleton to the membrane by binding simultaneously to the ß-spectrin subunit and to the transmembrane anion transporter.
Lazarides, Elias, Moon, Randall T.
core  

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Nature Communications, 2017
Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5 mutation resulting in a leucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was ...
Adam W. Avery, Michael E. Fealey, Fengbin Wang, A. Orlova, Andrew R. Thompson, David D. Thomas, T. Hays, E. Egelman   +7 more
semanticscholar   +1 more source

Iron overload in hereditary spherocytosis: Are genetic factors the cause?

British Journal of Haematology, EarlyView.
Summary Non‐transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next‐generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association ...
Lucie Donaty, Muriel Giansily‐Blaizot, Ivan Bertchansky, Séverine Cunat, Vincent Azoury, Perrine Mahe, Patricia Aguilar Martinez   +6 more
wiley   +1 more source

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease

British Journal of Haematology, EarlyView.
This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly, Pengyi Ding, Rasiqh Wadud, David C. Rees, John N. Brewin, John S. Gibson   +5 more
wiley   +1 more source

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. [PDF]

, 2015
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular ...
Abagyan, Ruben, Kufareva, Irina, Lenoir, Marc, Overduin, Michael   +3 more
core   +3 more sources

Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma

Cell Proliferation, EarlyView.
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the
Sicheng Bian, Jiangxia Cui, Xialin Zhang, Chongzhi Bai, Yanhong Tan, Zhuanghui Hao, Xingpeng Bu, Changxin Qu, Lili Sun, Leilei Lin, Qi Wang, Zhengrui Li, Xufeng Huang, Hengrui Liu, Ruo Wang, Yinghua Li, Hongwei Wang   +16 more
wiley   +1 more source

Mechanical characterization of spectrin at the molecular level

Scientific Reports
Spectrin, a large cytoskeletal protein, consists of a heterodimeric structure comprising α and β subunits. Here, we have studied the mechanics of spectrin filament as a major constituent of dendrites and dendritic spines.
Md Nahian Bin Hossain, Ashfaq Adnan
doaj   +1 more source