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Seminars in Reproductive Medicine, 2021
AbstractSperm DNA fragmentation refers to the accumulation of adducts as well as single- or double-strand DNA breaks and reflects the sperm DNA quality. Current data suggest that there are differences in sperm DNA quality among individuals with high or low fertility, and this observation has led to the idea that testing sperm DNA fragmentation could be
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AbstractSperm DNA fragmentation refers to the accumulation of adducts as well as single- or double-strand DNA breaks and reflects the sperm DNA quality. Current data suggest that there are differences in sperm DNA quality among individuals with high or low fertility, and this observation has led to the idea that testing sperm DNA fragmentation could be
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DNA fragmentation of sperm in automobile painters
Toxicology and Industrial Health, 2021Reproductive health is a major concern for workers constantly exposed to chemicals at work, especially in developing countries. The problems mainly stemmed from chronic exposure to the chemicals contained in paint thinner, which is mainly toluene, used during automobile painting.
Dicky Faizal Irnandi +2 more
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Sperm DNA fragmentation: causes and identification
Zygote, 2019SummarySperm DNA fragmentation is referred to as one of the main causes of male infertility. Failures in the protamination process, apoptosis and action of reactive oxygen species (ROS) are considered the most important causes of DNA fragmentation.
Thais Rose dos Santos Hamilton +1 more
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Sperm DNA Fragmentation: Consequences for Reproduction
2019DNA fragmentation, or the accumulation of single- and double-strand DNA breaks, is a common property of sperm, and an increase in the level of sperm DNA fragmentation is known to influence natural reproduction. The effect of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes remains controversial and is one ...
Luke, Simon +2 more
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Sperm DNA Fragmentation: Mechanisms of Origin
2019Spermatozoa have the task to deliver an intact paternal genome to the oocyte and to support a successful embryo development. The high levels of sperm DNA fragmentation (sDF) found in sub-/infertile men threat human reproduction and health of the offspring.
Muratori, Monica +3 more
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Sperm DNA Fragmentation and Fertility
Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss.Jessica, Marinaro, Peter N, Schlegel
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Sperm DNA fragmentation in men with malignancy
Fertility and Sterility, 2013To determine if men with malignancy have increased sperm DNA fragmentation compared with men presenting for sperm donation.Retrospective observational study.Tertiary-level fertility center.Eighty-nine men with cancer presenting for prophylactic semen cryopreservation and 35 men presenting for sperm donation.None.Sperm DNA fragmentation index (DFI ...
McDowell, Simon +4 more
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Sperm DNA Fragmentation and Base Oxidation
2013Sperm DNA damage has been shown to be a valuable diagnostic and prognostic biomarker for male infertility and assisted reproductive treatment (ART) outcome. It is linked to every fertility checkpoint from reduced fertilization rates, lower embryo quality and pregnancy rates to higher rates of spontaneous miscarriage and childhood diseases.
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Sperm DNA fragmentation: awakening the sleeping genome
Biochemical Society Transactions, 2007We have recently demonstrated that mammalian spermatozoa have the ability to degrade their DNA by a mechanism that is similar to apoptosis in somatic cells. When this mechanism is activated, the DNA is first degraded into loop-sized fragments by TOP2B (topoisomerase IIB).
J A, Shaman, Y, Yamauchi, W S, Ward
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