Results 101 to 110 of about 14,205 (205)

Male Mice Heterozygous for Protamine 1 and Protamine 2 Are Infertile, Displaying Sperm Damage and Retention of Protamine 2 Precursors, Transition Proteins, and Histones

Andrology, EarlyView.
ABSTRACT Background During spermiogenesis, protamines (PRMs) replace histones to hypercondense and protect sperm DNA. Rodents and primates express two PRMs (PRM1 and PRM2). Alterations of species‐specific PRM ratios are associated with sub‐ or infertility in mice and humans.
Gina Esther Merges, Christoph Wiesejahn, Mar Domingo‐Lopez, Simon Schneider, Andjela Kovacevic, Lena Arévalo, Hubert Schorle   +6 more
wiley   +1 more source

Deep‐Learning‐Based Profiling of Mouse Sperm Head and Neck Morphology Reveals Coordinated Structural Variation

Andrology, EarlyView.
ABSTRACT Background Mammalian sperm head morphology varies across species and dictates fertilization capability. Rodent sperm have asymmetric, hook‐shaped heads, complicating analysis. Despite widespread biomedical use, current tools poorly characterize these complex variations.
Gwidong Han, Seung Pyo Hong, Seung Jae Lee, Chunghee Cho   +3 more
wiley   +1 more source

The Sertoli Cell-Spermatid Junctional Complex: A Potential Avenue For Male Contraception [PDF]

, 2006
The Sertoli cell ectoplasmic specialization is a specialized domain of the calcium-dependent Sertoli-spermatid adherens junction. Structurally abnormal or absent Sertoli ectoplasmic specializations are associated with spermatid sloughing and subsequent ...
Wolski, Katja Margrit
core  

Localization of the KIFC1-like protein and microtubules in final spermatid in O. tankahkeei.

, 2013
The location of KIFC1-like protein and microtubules were checked by IF and IEM. (A) Microtubules were still visible in the cell but the manchette-like perinuclear structure was not so rigid around the nucleus (arrowhead).
Fu-Qing Tan (317434), Wan-Xi Yang (317438), Wei Wang (17594), He-Ming Yu (358709), Jun-Quan Zhu (358708)   +4 more
core   +1 more source

Atypical septate junctions maintain the somatic enclosure around maturing spermatids and prevent premature sperm release in Drosophila testis

Biology Open, 2019
Tight junctions prevent paracellular flow and maintain cell polarity in an epithelium. These junctions are also required for maintaining the blood-testis barrier, which is essential for sperm differentiation.
Pankaj Dubey, Tushna Kapoor, Samir Gupta, Seema Shirolikar, Krishanu Ray   +4 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Spermatid cysts elongate in the wrong direction in apkc or orb2 mutants.

, 2014
A) Frequency of testes that have at least one spermatid cyst polarized in the wrong orientation so that clustered spermatid cyst nuclei are found in the apical region instead of towards the base of the testis.
Sanjay Tyagi (8954), Shuwa Xu (115351), Paul Schedl (115354)   +2 more
core   +1 more source

A CCNA1 Missense Variant Associated With Chromatid Non‐Disjunction in Abnormal‐Headed Sperm and Male Infertility

Andrology, EarlyView.
ABSTRACT Background Macrozoospermia is a rare form of teratozoospermia characterized by tetraploids, large‐headed spermatozoa with multiple flagella, usually caused by bi‐allelic AURKC mutations. The etiology of atypical phenotypes with a lower proportion of large headed spermatozoa and single flagella however often remains unresolved.
Aurore Perrin, Frédéric Morel, Zeina Wehbe, Cynthia Frapsauce, Nadia Gueganic, Corinne Tous, Séverine Commet, Laura Dijols, Audrey Basinko, Nathalie Douet‐Guilbert, Célia Tebbakh, Zine‐Eddine Kherraf, Pierre F. Ray, Charles Coutton, Guillaume Martinez   +14 more
wiley   +1 more source

The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon’s head to tail

, 2016
Male infertility due to abnormal spermatozoa has been reported in both animals and humans, but its pathogenic causes, including genetic abnormalities, remain largely unknown.
Hao, Xiao-Xia, Chawn-Shang Chang, Liu, Yi-Xun, Aalia Batool, Batool, Alia, C Yan Cheng, Cheng, C. Yan, Xiao-Xia Hao, Su-Ren Chen, Chang, Chawn-Shang, Yi-Xun Liu, Yu-Qian Wang, Wang, Yu-Qian, Chen, Su-Ren   +13 more
core   +1 more source

Identification and characterization of dystrophin-locus-derived testis-specific protein: A testis-specific gene within the intronic region of the rat dystrophin gene

The Journal of Reproduction and Development
The mammalian X chromosome exhibits enrichment in genes associated with germ cell development. Previously, we generated a rat model of Becker muscular dystrophy (BMD) characterized by an in-frame mutation in the dystrophin gene, situated on the X ...
Keitaro YAMANOUCHI, Shizuka KATO, Yukie TANAKA, Masanari IKEDA, Yukina OSHIMO, Takanori SHIGA, Kei HATAMOTO, James CHAMBERS, Takuya IMAMURA, Ryuji HIRAMATSU, Kazuyuki UCHIDA, Fuko MATSUDA, Takashi MATSUWAKI, Tetsuya KOHSAKA   +13 more
doaj   +1 more source