Results 21 to 30 of about 10,843 (205)

Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

Asian Journal of Andrology, 2015
Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF ...
Carol Coughlan, Helen Clarke, Rachel Cutting, Jane Saxton, Sarah Waite, William Ledger, Tinchiu Li, Allan A Pacey   +7 more
doaj   +1 more source

Intracytoplasmic Injection Using Spermatids and Subsequent Pregnancies: Round Versus Elongated Spermatids [PDF]

Journal of Assisted Reproduction and Genetics, 2002
The purpose of this clinical trial study was to report the outcome of intracytoplasmic injection of round (RS) and elongated (ES) spermatids retrieved from the testis of nonobstructive men. Seven and three cycles using RS and ES injections were performed, respectively.
Mohammad A, Khalili, Abbas, Aflatoonian, Panos M, Zavos   +2 more
openaire   +2 more sources

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

Asian Journal of Andrology, 2015
The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo, Josep Maria Estanyol, Josep Lluis Ballescà, Rafael Oliva   +3 more
doaj   +1 more source

An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads

Cell Reports, 2021
Summary: Membrane curvature recruits Bin-Amphiphysin-Rvs (BAR)-domain proteins and induces local F-actin assembly, which further modifies the membrane curvature and dynamics. The downstream molecular pathway in vivo is still unclear. Here, we show that a
Tushna Kapoor, Pankaj Dubey, Seema Shirolikar, Krishanu Ray   +3 more
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

New insights into the regulation of cholesterol efflux from the sperm membrane

Asian Journal of Andrology, 2015
Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
doaj   +1 more source

Spermatids as gametes: indications and limitations [PDF]

Human Reproduction, 1998
The feasibility of achieving viable embryos, developing to term after transfer into the uterus, by fertilizing oocytes with spermatids has been demonstrated both in animal studies and in preliminary human clinical trials. Here we review the current clinical indications of spermatid conception and discuss the predictable success rates associated with ...
J, Tesarik, M, Sousa, E, Greco, C, Mendoza   +3 more
openaire   +2 more sources

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction?

Clinics
Intracytoplasmic injection with testicular spermatozoa has become a routine treatment in fertility clinics. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia.
Veerle Vloeberghs, Greta Verheyen, Herman Tournaye   +2 more
doaj   +1 more source

Search and identification of spermatozoa and spermatids in the ejaculate of non-obstructive azoospermic patients

International Brazilian Journal of Urology, 2005
OBJECTIVE: To search and to identify spermatozoa and spermatids, present in the ejaculate of non-obstructive azoospermic patients. MATERIALS AND METHODS: 27 patients, aged between 18 and 48 years, with initial diagnosis compatible with non-obstructive ...
Odival Timm Jr, Agnaldo P. Cedenho, Deborah M. Spaine, Marcia H.P. Buttignol, Renato Fraietta, Valdemar Ortiz, Miguel Srougi   +6 more
doaj   +1 more source