Results 31 to 40 of about 14,205 (205)
Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?
Asian Journal of Andrology, 2015 This chapter explores the possibility that capacitation and apoptosis are linked processes joined by their common dependence on the continued generation of reactive oxygen species (ROS).
Robert J Aitken +2 more
doaj +1 more source
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells
Advanced Science, EarlyView.BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li +8 more
wiley +1 more source
aPKC expression in spermatid cysts.
, 2014 A) Stages of spermatogenesis. Germline cysts are in yellow, while the somatic cyst cells are labeled in dark pink (posterior or head cyst cell) and light pink (anterior or tail cyst cell) respectively. SC, stem cell; SMG, spermatogonia; SMC, spermatocyte;
Sanjay Tyagi (8954) +2 more
core +1 more source
Three-dimensional reconstruction of rat sperm using volume electron microscopy
Acta Biochimica et Biophysica SinicaThree-dimensional (3D) reconstruction serves as a crucial instrument for the analysis of biological structures. In particular, a comprehensive and accurate 3D ultrastructural examination of rat sperm is vital for understanding and diagnosing male ...
Liu Jiazheng +7 more
doaj +1 more source
Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage
Asian Journal of Andrology, 2015 Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF ...
Carol Coughlan +7 more
doaj +1 more source
Cell Reports, 2021 Summary: Membrane curvature recruits Bin-Amphiphysin-Rvs (BAR)-domain proteins and induces local F-actin assembly, which further modifies the membrane curvature and dynamics. The downstream molecular pathway in vivo is still unclear. Here, we show that a
Tushna Kapoor +3 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu +23 more
wiley +1 more source
Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility
Asian Journal of Andrology, 2015 The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo +3 more
doaj +1 more source
Sprn is expressed in the nebenkern throughout spermatid elongation.
, 2014 Endogenous Sprn expression is first detectable, though weak, in meiosis I and II, when mitochondria form first aggregates (arrowheads). Sprn expression increases at the spermatid nebenkern and persists throughout spermatid elongation (arrows), but is ...
Jieyan V. Chen (635710) +1 more
core +1 more source
New insights into the regulation of cholesterol efflux from the sperm membrane
Asian Journal of Andrology, 2015 Cholesterol is an essential component of the mammalian plasma membrane because it promotes membrane stability without comprising membrane fluidity. Given this important cellular role, cholesterol levels are tightly controlled at multiple levels.
Tamara Leahy, Bart M Gadella
doaj +1 more source