Results 61 to 70 of about 10,346 (209)

Co-culture of mouse spermatogonial stem cells with sertoli cell as a feeder layer, stimulates the proliferation and spermatogonial stemness profile

Middle East Fertility Society Journal, 2018
Objectives: Sertoli cells effect the fate map of spermatogonial stem cells (SSCs) to self-renew via providing the special microenvironments. Maintenance of proliferation and self-renewal activity of SSCs may be usable as a therapeutic strategy, leads to ...
Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi   +1 more
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Spermatogonial Stem Cell Culture in Oncofertility

Urologic Clinics of North America, 2020
Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility ...
Sherin, David, Kyle E, Orwig
openaire   +2 more sources

Evaluation of the Effect of Follicle Stimulating Hormone (FSH) on Survival and Colonization of Caprine Spermatogonial Stem Cells during in Vitro Culture

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Spermatogonial stem cells are specific cells that have the ability of self-renewal and differentiation. These cells play an essential role in maintaining spermatogenesis and fertility.
Hamed Kadivarian, Peyman Rahimi-Feyli, Aliasghar Moghaddam, Samad Alimohammadi   +3 more
doaj  

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

MEK/ERK signaling directly and indirectly contributes to the cyclical self‐renewal of spermatogonial stem cells [PDF]

, 2013
Coordination of stem cell fate is regulated by extrinsic niche signals and stem cell intrinsic factors. In mammalian testes, spermatogonial stem cells maintain constant production of abundant spermatozoa by alternating between self-renewal and ...
Saga, Yumiko, Hasegawa, Kazuteru, Namekawa, Satoshi H   +2 more
core   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal [PDF]

, 2006
Aging is evident in most tissues and organ systems, but the mechanisms of aging are difficult to identify and poorly understood. Here, we test the hypothesis that aging results in uncorrected defects in stem cell and/or niche function, which lead to ...
Orwig, Kyle E, Brinster, Ralph L, Avarbock, Mary R, Ryu, Buom-Yong, Oatley, Jon M   +4 more
core   +1 more source

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma [PDF]

, 2019
Glaucoma is characterized by retinal ganglion cell (RGC) degeneration and is the second leading cause of blindness worldwide. However, current treatments such as eye drop or surgery have limitations and do not target the loss of RGC. Regenerative therapy
Qian, Yan, Chan, Wai Yee, Chan, Thomas Ting Hei, Lee, Tin Lap, Hou, Hei Wan, Feng, Bo, Luk, Chun Shui, Li, Kit, Liu, Yuen Hang, Ng, Tsz Kin, Suen, Hoi Ching, Rudd, John A., Hobbs, Robin, Li, Ingrid, Mak, Heather Kayew, Jiang, Xiaohua, Qi, Huayu, Lee, Wing Tung, Leung, Kai Shun, Ng, Judy Kin Wing, Gao, Lin, Liao, Jinyue   +21 more
core   +1 more source