Results 141 to 150 of about 863 (166)

Circulating spexins in children with obesity: relation to cardiometabolic risk

European Journal of Clinical Nutrition, 2021
The role of spexin (SPX) in energy metabolism, endocrinal homeostasis, and vasculopathy is emerging. However, scarce data are available about its role in childhood obesity and obesity-related vasculopathy. Hence, we aimed to assess the level of SPX in obese and normal-weight children, and to correlate it with aortic distensibility (AD) and aortic ...
Nouran Y. Salah, Dina Abu Zeid, Rania N. Sabry, Reham F. Fahmy, Mona A. El Abd, Eman Awadallah, Azza Omran, Yasmin G. El Gendy   +7 more
openaire   +2 more sources

Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation

Peptides, 2010
Spexin (SPX, also called NPQ) is a recently identified, highly conserved peptide which is processed and secreted. We analysed the SPX gene and its protein product in the rat adrenal gland to ascertain whether SPX is involved in the regulation of corticosteroid secretion of and growth of adrenocortical cells.
RUCINSKI M, PORZIONATO, ANDREA, ZIOLKOWSKA A, SZYSZKA M, MACCHI, VERONICA, DE CARO, RAFFAELE, MALENDOWICZ LK   +6 more
openaire   +3 more sources

Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor

Biochemical and Biophysical Research Communications, 2020
Spexin (SPX) acts as a neuropeptide with pleiotropic functions that can participate in anxiety regulation. Corticotropin releasing factor (CRF) is widely expressed in brain tissues and associated with depression and anxiety and addiction. With the anxious mice under chronic unpredictable stress, we found SPX mRNA expression level in the hippocampus of ...
Min Zhuang, Qi Lai, Chunju Yang, Yanhua Ma, Baomin Fan, Zhaoxiang Bian, Chengyuan Lin, Jin Bai, Guangzhi Zeng   +8 more
openaire   +2 more sources

The Role of Spexin in Social Stress

2021
Social stress arises from one’s inability to cope with their social environment. Understanding how social stress affects our brains is essential, as long-term exposure will lead to various physiological and mental illnesses. This thesis investigates the impact of social stress on Spexin neuron and its regulatory system in male Nile tilapia.
openaire   +1 more source

Structure and functions of spexin as a new neuroendocrine signal

Journal of Experimental and Clinical Medicine, 2022
Spexin (SPX ) is a recently discovered endogenous peptide consisting of 14 amino acids. It was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene family and are also endogenous ligands of GAL2 and GAL3 receptors. The amino acid sequence of the SPX peptide is relatively conserved in vertebrates and invertebrates.
DARAKCI, Özge, BOZKURT, Ayhan
openaire   +2 more sources

Spexin in the physiology of pancreatic islets—mutual interactions with insulin

Endocrine, 2018
Spexin is an interesting peptide, which may play an important role in the regulation of the metabolic homeostasis of an organism. Current knowledge on spexin expression, secretion, and influence on tissues and endocrine glands is very limited. We investigated spexin localization in the endocrine pancreas and measured its in vitro secretion from ...
Maciej, Sassek, Pawel A, Kolodziejski, Dawid, Szczepankiewicz, Ewa, Pruszynska-Oszmalek   +3 more
openaire   +2 more sources

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018
Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX inhibits food intake and reduces body weight. In obese humans, SPX is the most down-regulated gene in fat. Therefore, SPX might be involved in the regulation of lipid metabolism.
Pawel A, Kolodziejski, Ewa, Pruszynska-Oszmalek, Maciej, Micker, Marek, Skrzypski, Tatiana, Wojciechowicz, Patryk, Szwarckopf, Kinga, Skieresz-Szewczyk, Krzysztof W, Nowak, Mathias Z, Strowski   +8 more
openaire   +2 more sources

Spexin Modulates Functions of Rat Endocrine Pancreatic Cells

Pancreas, 2018
Objectives Spexin is a peptide whose action is poorly understood but which is expressed in many tissues. This encouraged us to investigate the potential role of spexin in the regulation of pancreatic secretion. Methods Cells/islets were incubated with different concentrations of ...
Maciej, Sassek, Pawel A, Kolodziejski, Mathias Z, Strowski, Leszek, Nogowski, Krzysztof W, Nowak, Pawel, Mackowiak   +5 more
openaire   +2 more sources

Spexin as a potential biomarker for autoimmune inflammation in Graves’ disease

Journal of Investigative Medicine
Graves’ disease (GD) is an autoimmune thyroid disorder characterized by excessive thyroid hormone production driven by thyroid-stimulating hormone (TSH) receptor antibodies (TRAb). This study aimed to investigate the relationship between serum spexin (SPX) levels, TRAb levels, thyroid ultrasound findings, and metabolic parameters in GD patients while ...
Betul Cigdem Yortanli, Ummugulsum Can, Mehmet Yortanli, Korhan Kollu, Selma Ozlem Celikdelen, Gulsum Tugce Catak, Oguzhan Aksu, Muhammet Cemal Kizilarslanoglu   +7 more
openaire   +2 more sources

Role of Spexin in Central Reproductive Control

This thesis investigates the multifunctional neuropeptide spexin, as a neuromodulator of reproductive factors in the brain as a consequence of chronic social stress. Using the Nile tilapia model, chronic social stress inhibited spexin’s receptor in the brain. Spexin signals were observed closely with reproductive neurons.
openaire   +1 more source