Results 121 to 130 of about 130,558 (351)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

Frontiers in Microbiology
The present study investigated the synthesis and biological applications of green, economical, and multifunctional silver and gold nanoparticles (TSAgNPs and TSAuNPs) using the ethnomedical important medicinal plant Thespesia lampas for biological ...
Sunayana Nath, Ritis Kumar Shyanti, Ritis Kumar Shyanti, Rana Pratap Singh, Manoj Mishra, Bhawana Pathak   +5 more
doaj   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

Frontiers in Toxicology
There are currently no available cell lines for the ecologically relevant colonial waterbird species, the double-crested cormorant (DCCO). DCCOs are high trophic level aquatic birds that are used for routine contaminant monitoring programs in the ...
Tasnia Sharin, Doug Crump, Jason M. O’Brien   +2 more
doaj   +1 more source

VLT/UVES Abundances in Four Nearby Dwarf Spheroidal Galaxies. II. Implications for Understanding Galaxy Evolution [PDF]

, 2003
Eline Tolstoy, Kim A. Venn, Matthew Shetrone, Francesca Primas, Vanessa Hill, Andreas Kaufer, Thomas Szeifert   +6 more
openalex   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Differences of statin activity in 2D and 3D pancreatic cancer cell cultures

Drug Design, Development and Therapy, 2017
Miglė Paškevičiūtė,1 Vilma Petrikaitė1,21Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Department of Biothermodynamics and Drug Design, Vilnius University Institute of ...
Paškevičiūtė M, Petrikaitė V
doaj  

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids

, 2022
Kevin Tröndle, Guilherme Miotto, Ludovica Rizzo, Roman Pichler, Fritz Koch, Peter Koltay, Roland Zengerle, Soeren S. Lienkamp, Sabrina Kartmann, Stefan Zimmermann   +9 more
openalex   +2 more sources

Detection of Heterogeneous Cells in Cell Spheroids by Applying High-Frequency Second-Order Sensitivity Matrix Electrical Impedance Tomography (HSSM-EIT) [PDF]

, 2022
Songshi Li, Daisuke Kawashima, Zengfeng Gao, Masahiro Takei   +3 more
openalex   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source