Results 101 to 110 of about 60,705 (304)

Tracking Spatiotemporal Extracellular Matrix Evolution and Tissue Fusion in 3D Microtissues via Click Chemistry‐Based Metabolic Labelling

open access: yesAdvanced Healthcare Materials, EarlyView.
Metabolic labeling of nascent proteins in 3D microtissue spheroids provides a powerful analytical approach for large‐scale tissue engineering. Incorporation of non‐canonical amino acids with fluorescent tagging enables spatiotemporal investigation of extracellular matrix deposition and its evolution during multicellular tissue development and fusion ...
Theresa Koenig   +3 more
wiley   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

open access: yesAdvanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină   +2 more
wiley   +1 more source

On Spheroidal Harmonics [PDF]

open access: yesProceedings of the Edinburgh Mathematical Society, 1914
Ellipsoidal harmonics are defined to be those solutions of Laplace's equation(where x, y, z are rectangular coordinates) which are useful in problems relating to ellipsoids. If the equationrepresents a family of confocal quadrics, it is known that the ellipsoidal harmonics belonging to the family are products of the formwhere l1, l2… are constants: one
openaire   +1 more source

Determination of the spheroid-microdevice contact zone.

open access: yes, 2019
(A) A 3D confocal image of a stained living spheroid in the microdevice showing the imaging limitations to access the whole spheroid. (B) Bright field microscopy image taken directly after the spheroid removal from the device showing the pillar imprints (
Stanislas Larnier (6729746)   +7 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

open access: yesAdvanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu   +5 more
wiley   +1 more source

Simulated spheroid assay.

open access: yes, 2014
(A) Collective behavior in a simulation initiated with a two-dimensional "spheroid" of cells, on substrates of varying stiffness. (B) Time lapse showing a sprouting spheroid on a 10kPa substrate. Time in MCS. Panels A and B represent a 0.75×0.75 mm2 area
René F. M. van Oers (615319)   +4 more
core   +1 more source

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

open access: yesAdvanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo   +6 more
wiley   +1 more source

Spheroid size.

open access: yes, 2015
Size measurements of human normal dermal fibroblast (A), colon cancer (B), bladder cancer (C), and metastatic breast cancer (D) spheroids. Left panel: representative fluorescence microscopy images of a spheroid just after electroporation (8 pulses of 100
Laure Gibot (833330)   +4 more
core   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

open access: yesAdvanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky   +4 more
wiley   +1 more source

TTR spheroid oligomers and protofibrils.

open access: yes, 2012
A. 1×1 µm2 AFM height contrast image of a mixed population of spheroid oligomers and short protofibrils. Black arrows point out examples of spheroid oligomers with various shapes and sizes.
Ana M. Damas (44978)   +4 more
core   +1 more source

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