Results 121 to 130 of about 67,710 (307)
Establishment of a Sensitized 3D Spheroid Cancer Cell Model for Enhanced Anti-Cancer Drug Discovery
Methods and ProtocolsThree-dimensional (3D) spheroid cancer models provide enhanced physiological relevance relative to traditional monolayer cultures but often demonstrate restricted drug responsiveness due to their dense architecture, hypoxic gradients, and diminished ...
Ee Wern Tan +4 more
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Tumor spheroid growth in culture.
, 2019 (A) HT1080 cells (5000 cells) engineered to express fluorescent proteins were grown in culture under conditions to promote spheroid formation. Maximum intensity projections of cells imaged 3 days (A), 7 days (B) or 10 days (C) after plating are shown ...
Iris Kemler (6425138) +8 more
core +1 more source
Advanced Materials Technologies, EarlyView.Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina +5 more
wiley +1 more source
Marine DrugsTriple-negative breast cancers (TNBC) lack estrogen, progesterone, and express little, if any, HER2 receptors on their surface. No targeted therapies exist for this aggressive form of breast cancer.
Esther A. Guzmán +3 more
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Recent Advances in Light‐Addressable Electrochemistry for Spatially Resolved Applications
Advanced Materials Technologies, EarlyView.This comprehensive review highlights light‐addressable electrochemistry as a powerful tool that uses light to control localized chemical reactions on unstructured semiconductor surfaces. The work evaluates advanced strategies to optimize electrode materials for enhanced spatial resolution and stability. Furthermore, it showcases diverse applications in
Nhi Trang Vo +2 more
wiley +1 more source
Differences of statin activity in 2D and 3D pancreatic cancer cell cultures
Drug Design, Development and Therapy, 2017 Miglė Paškevičiūtė,1 Vilma Petrikaitė1,21Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Department of Biothermodynamics and Drug Design, Vilnius University Institute of ...
Paškevičiūtė M, Petrikaitė V
doaj
Advanced Optical Materials, EarlyView.Spherical liquid crystal polymer microlasers with a bipolar configuration confine lasing to a single equatorial plane, allowing precise control over where the laser emission is generated. The anisotropic refractive index profile additionally lifts the energy degeneracy of azimuthal whispering gallery modes, which causes a characteristic splitting into ...
David Ripp +5 more
wiley +1 more source
Advanced ScienceTumor development and progression involve biophysical changes across spatial scales, from the subcellular to the multicellular tissue scale. While cells are known to dynamically regulate their volumes and mechanics in dependence of cell state and ...
Vaibhav Mahajan +13 more
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A Simple Model to Study Mosaic Gene Expression in 3D Endothelial Spheroids
Journal of Cardiovascular Development and DiseaseAims: The goal of this study was to establish a simple model of 3D endothelial spheroids with mosaic gene expression using adeno-associated virus (AAV) transduction, with a future aim being to study the activity of post-zygotic mutations common to ...
Lucinda S. McRobb +3 more
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Spheroid growth characterization.
, 2015 (A) Spheroid growth assay. Representative images of spheroids of three different sizes. Scale bars, 100 μm. (B–D) The change of diameter, solidity, and circularity. Data represent the mean ± standard deviation (SD) of one experiment (n = 30).
Xue Gong (144222) +7 more
core +1 more source