Asymmetric synthesis of vicinal amino alcohols: xestoaminol C, sphinganine and sphingosine
Organic & Biomolecular Chemistry, 2008 The highly diastereoselective anti-aminohydroxylation of alpha,beta-unsaturated esters, via conjugate addition of lithium (S)-N-benzyl-N-(alpha-methylbenzyl)amide and subsequent in situ enolate oxidation with (+)-(camphorsulfonyl)oxaziridine, has been used as the key step in the asymmetric synthesis of N,O-diacetyl xestoaminol C (41% yield over 8 steps)
Abraham, E +5 more
openaire +2 more sources
Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. [PDF]
, 2019 Age and Alzheimer's disease (AD) share some common features such as cognitive impairments, memory loss, metabolic disturbances, bioenergetic deficits, and inflammation.
Brewer, Gregory J, Dong, Yue
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Long-chain bases, phosphatidic acid, MAPKs, and reactive oxygen species as nodal signal transducers in stress responses in Arabidopsis [PDF]
, 2015 Due to their sessile condition, plants have developed sensitive, fast and successful ways to contend to environmental changes. These mechanisms operate as informational wires conforming extensive and intricate networks that are connected in several ...
Mariana Saucedo-GarcÃa +2 more
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Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells [PDF]
, 2014 FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form.
Lee, WJ +5 more
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Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome? [PDF]
, 2018 Aims/hypothesis: Sphingolipid synthesis is typically initiated by the conjugation of l-serine and palmitoyl-CoA, a reaction catalysed by serine palmitoyltransferase (SPT). SPT can also metabolise other acyl-CoAs (C12 to C18) and other amino acids such as
Bianchi, R. +10 more
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Correlation of the plasma sphingoid base profile with results from oral glucose tolerance tests in gestational diabetes mellitus [PDF]
, 2017 Oral glucose tolerance test (OGTT) is usually insufficient to accurately predict the risk for type 2 diabetes mellitus (T2DM), it is therefore necessary to identify an additional biomarker that would most likely improve the accuracy of OGTT.
Hornemann, Thorsten, Khan, Abad
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Journal of Agriculture and Food ResearchInflammatory bowel disease (IBD) is characterized by chronic gastrointestinal inflammation and gut microbiota dysbiosis. This study evaluated the protective effects of cooked oat bran (COB) on dextran sulfate sodium (DSS)-induced colitis in mice.
Qixin Gu +3 more
doaj +1 more source
Identification and quantitation of free ceramides in human platelets
Journal of Lipid Research, 1972 Free ceramides were isolated from human platelets. Their structures were unequivocally determined by gas–liquid chromatography–mass spectrometry of the trimethylsilyl ether derivatives.
William Krivit, Sven Hammarström
doaj +1 more source
Nature CommunicationsAfter recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation.
Marvin Hering +15 more
doaj +1 more source
Effects of feeding a fumonsin (FB₁) naturally contaminated corn at various levels, with and without 2 adsorbents on the growth performance, blood, and liver chemistry of nursery pigs [PDF]
Title from PDF of title page (University of Missouri--Columbia, viewed on January 19, 2010)M.S. University of Missouri--Columbia 2009.Thesis advisor: Dr.
Turner, Shelly Elizabeth, 1985-
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