Results 91 to 100 of about 9,200 (222)

Nanoflow-nanospray mass spectrometry metabolomics reveals disruption of the urinary metabolite profiles of HIV-positive patients on combination antiretroviral therapy [PDF]

, 2017
Background: The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal ...
Abdul-Sada, Alaa, Bremner, Stephen A, Chetwynd, Andrew J, Gilleece, Yvonne, Hill, Elizabeth M, Holt, Stephen G, Samarawickrama, Amanda, Vera, Jaime H   +7 more
core   +1 more source

HEPES in Cell Culture Alters the Multi‐Omics Profile Exhibited by Gaucher Disease Fibroblasts

Journal of Cellular Biochemistry, Volume 127, Issue 1, January 2026.
ABSTRACT Lysosomal function can be affected by components in cell culture. This in turn may influence cellular metabolism and, consequently, research and diagnostics outcomes. One such component is the commonly used pH buffer 4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid (HEPES).
Eleonore M. Corazolla, Bauke V. Schomakers, Maria M. Trętowicz, Jill Hermans, Michel van Weeghel, Frédéric M. Vaz, Mia L. Pras‐Raves, Karen Ghauharali‐van der Vlugt, Femke S. Beers‐Stet, Susanna M. I. Goorden, Judith Jansen‐Meijer, Georges E. Janssens, Carla E. M. Hollak, Riekelt H. Houtkooper, André B. P. van Kuilenburg   +14 more
wiley   +1 more source

Mechanistic interplay between ceramide and insulin resistance [PDF]

, 2017
Recent research adds to a growing body of literature on the essential role of ceramides in glucose homeostasis and insulin signaling, while the mechanistic interplay between various components of ceramide metabolism remains to be quantified.
A Gómez-Muñoz, AD Batheja, AH Merrill, APK B., BM Barth, BM Barth, CD Camell, CRH Raetz, D Hartmann, D Nikolić, DT Gillespie, EA Dennis, GNT Csardi, H Aburasayn, J Dupuis, JC Florez, JR Ussher, K Kitatani, M Hayes, M Straczkowski, MR Irvin, R Saxena, S Fayyaz, S Gupta, SaF Morad, SM Turpin, TD Mullen, V Shahrezaei, W Hu, W Ruangsiriluk, W Wronowska, WL Holland, WL Holland, X Prieur, Y Benjamini   +34 more
core   +4 more sources

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change

Journal of Pharmaceutical Analysis, 2019
Although compatibility is highly advocated in traditional Chinese medicine (TCM), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of TCM “Eighteen Incompatible Medicaments”
Yan-Yan Chen, Juan Shen, Yu-Ping Tang, Jin-Gao Yu, Jing Wang, Shi-Jun Yue, Jie Yang, Jia-Qian Chen, Li-Mei Feng, Zhen-Hua Zhu, Wei-Wei Tao, Li Zhang, Jin-Ao Duan   +12 more
doaj   +1 more source

Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis[S]

Journal of Lipid Research, 2020
The levels and composition of sphingolipids and related metabolites are altered in aging and in common disorders such as diabetes and cancers, as well as in neurodegenerative, cardiovascular, and respiratory diseases.
Vincent Mignard, Nolwenn Dubois, Didier Lanoé, Marie-Pierre Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, François Paris, François M. Vallette, Lisenn Lalier   +9 more
doaj   +1 more source

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. [PDF]

, 2015
Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood.
Bucci M, Cantalupo A, Di Lorenzo A, Galvani S, Giordano FJ, Jiang XC, Kothiya M, Obinata H, SOLIN, HEIKKI LAURI ABEL, ZHANG, YING   +9 more
core   +1 more source

Early Childhood Dietary Exposure of Aflatoxins and Fumonisins in Tanzania: Role in Child Stunting and Possible Interventions (2003–2024)

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Childhood stunting is a major public health concern, and dietary exposure to aflatoxins and fumonisins during early life is associated with child stunting in Tanzania. The causal link between aflatoxin and/or fumonisin exposure and child stunting has been less well explained.
Clara Mollay
wiley   +1 more source

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells [PDF]

, 2013
Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases such as cancer and pulmonary arterial hypertension. We have synthesized inhibitors that are selective for the two isoforms of sphingosine kinase (SK1 and SK2) that catalyze the ...
Bittman, Robert, Byun, Hoe-Sup, Macritchie, Neil, Pyne, Nigel J, Pyne, Susan   +4 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source