Results 81 to 90 of about 8,836 (207)

Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells*

Journal of Biological Chemistry, 2002
The longevity assurance gene (LAG1) and its homolog (LAC1) are required for acyl-CoA-dependent synthesis of ceramides containing very long acyl chain (e.g.
Krishnan Venkataraman, C. Riebeling, J. Bodennec, H. Riezman, J. Allegood, M. C. Sullards, Alfred H. Merrill, A. Futerman   +7 more
semanticscholar   +1 more source

Chilling Accumulation Shapes Transcriptomic Responses to Warming Exposure During Grapevine Deacclimation

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT During winter, grapevine (Vitis vinifera) bud dormancy and cold hardiness are regulated by complex interactions between chilling accumulation and warm temperature cues. However, the molecular mechanisms underlying physiological transitions during winter remain poorly understood.
Hongrui Wang, Jason P. Londo
wiley   +1 more source

Synthesis of sphinganine-containing alpha-galactosylceramides

, 2006
Glycosphingolipids are biologically important molecules located in the external surface of eukaryotic cells. They have been shown to have antitumor and immunostimulatory activity.
Ndonye, Rachel Mwikali
core   +1 more source

Retraction: A highly concise and practical route to clavaminols, sphinganine and (+)-spisulosine via indium mediated allylation of α-hydrazino aldehyde and a theoretical insight into the stereochemical aspects of the reaction

RSC Advances, 2013
Retraction of ‘A highly concise and practical route to clavaminols, sphinganine and (+)-spisulosine via indium mediated allylation of α-hydrazino aldehyde and a theoretical insight into the stereochemical aspects of the reaction’ by Menaka Pandey et al.,
M. Pandey, P. Chowdhury, A. Dutta, Pradeep Kumar, S. Pal   +4 more
semanticscholar   +1 more source

Synthesis of d-erythro-Sphinganine through Serine-Derived α‑Amino Epoxides

, 2016
A total synthesis of d-erythro-sphinganine [(2S,3R)-2-amino­octa­decane-1,3-diol] starting from commercial N-tert-butyl­oxy­carbonyl-l-serine methyl ester is described.
Paola Bonaccorsi (1795771), Antonella Leggio (1795759), Carlo Siciliano (1795765), Anna Barattucci (1663564), Maria Luisa Di Gioia (1795768), Lucio Minuti (1663570), Andrea Temperini (1663567), Emanuela Romio (1795762)   +7 more
core   +1 more source

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

Journal of Biological Chemistry, 1993
Fumonisins, mycotoxins produced by Fusarium moniliforme and a number of other fungi, cause neuronal degeneration, liver and renal toxicity, cancer, and other injury to animals. Recent work with rat hepatocytes (Wang, E., Norred, W. P., Bacon, C.
A. H. Merrill, G. van Echten, Elaine Wang, Konrad Sandhoff   +3 more
semanticscholar   +1 more source

Genetic ancestry–concordant ceramide metabolism and response to androgen receptor pathway inhibition in metastatic castration‐resistant prostate cancer

Cancer, Volume 132, Issue 11, 1 June 2026.
Abstract Background The authors observed differences in response between Black and White patients with metastatic castration‐resistant prostate cancer (mCRPC) who were treated prospectively with androgen receptor pathway inhibition (ARPI) in the Abi Race and PANTHER studies.
Sean A. Piwarski, Lauren E. Howard, Morgan A. Paul, Nick Bachelder, Bonnie LaCroix, Angela Clayton, Donna Allen, Julie Kephart, Andrew J. Armstrong, Steven R. Patierno, Daniel J. George, Terry Hyslop, Jennifer A. Freedman   +12 more
wiley   +1 more source

Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change

Journal of Pharmaceutical Analysis, 2019
Although compatibility is highly advocated in traditional Chinese medicine (TCM), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of TCM “Eighteen Incompatible Medicaments”
Yan-Yan Chen, Juan Shen, Yu-Ping Tang, Jin-Gao Yu, Jing Wang, Shi-Jun Yue, Jie Yang, Jia-Qian Chen, Li-Mei Feng, Zhen-Hua Zhu, Wei-Wei Tao, Li Zhang, Jin-Ao Duan   +12 more
doaj   +1 more source

Safety and efficacy of a feed additive consisting of fumonisin esterase produced with Komagataella phaffiiNCAIM (P) Y001485 for all terrestrial species (Dr. Bata Ltd.) [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of fumonisin esterase produced with the genetically modified strain Komagataella phaffii NCAIM (P) Y001485 as a technological feed additive (functional group: substances for reduction of the contamination of feed by ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Secundino López‐Puente, Montserrat Anguita, Matteo L. Innocenti, Jordi Ortuño   +20 more
europepmc   +2 more sources

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

Journal of Biological Chemistry, 1992
Serine palmitoyltransferase, 3-dehydrosphinganine reductase and sphinganine N-acyltransferase are responsible for the first steps in sphingolipid biosynthesis forming 3-oxosphinganine, sphinganine, and dihydroceramide, respectively.
E. Mandon, I. Ehses, J. Rother, G. van Echten, K. Sandhoff   +4 more
semanticscholar   +1 more source