Results 81 to 90 of about 9,200 (222)

A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry : application to the characterisation of metabolites in rat urine [PDF]

, 2019
A comprehensive Collision Cross Section (CCS) library was obtained via Travelling Wave Ion Guide mobility measurements through direct infusion (DI). The library consists of CCS and Mass Spectral (MS) data in negative and positive ElectroSpray Ionisation (
Bouwmeester, Robbin, Coen, Muireann, Gethings, Lee A, Lai, Steven, Langridge, James I, Letertre, Marine PM, Martens, Lennart, McCullagh, Michael, Munjoma, Nyasha C, Nicholson, Jeremy K, Nye, Leanne C, Plumb, Robert S, Swann, Jonathan R, Vissers, Johannes PC, Williams, Jonathan P, Wilson, Ian D   +15 more
core   +2 more sources

Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Asian Pacific Journal of Cancer Prevention
Cancer cells exhibit selective metabolic reprogramming to promote proliferation, invasiveness, and metastasis. Sphingolipids such as sphingosine and sphinganine have been reported to modulate cell death processes in cancer cells. However, the potential of extracellular sphinganine and its mimetic compounds as inducers of cancer cell death has not been ...
Nandangiri, Rasika, T N, Seethamma, Raj, Ajay Kumar, Lokhande, Kiran B., Khunteta, Kratika, Hebale, Ameya, Kothari, Haet, Patel, Vaidehi, Sarode, Sachin C, Sharma, Nilesh Kumar   +9 more
openaire   +2 more sources

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

Sphingolipids in Emotional Well‐Being

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Sphingolipids are essential constituents of neuronal membranes and are increasingly recognized as contributors to the key behavioral manifestations associated with emotional well‐being. ABSTRACT Emotional well‐being is a multifactorial concept, which comprises not only life quality of human individuals, but also their mental and physical health.
L. S. Kalinichenko, I. Zoicas, C. Mühle, J. Kornhuber, C. P. Müller   +4 more
wiley   +1 more source

Overexpression of the Tomato Asc-1 Gene Mediates High Insensitivity to AAL Toxins and Fumonisin B1 in Tomato Hairy Roots and Confers Resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica Plants

Molecular Plant-Microbe Interactions, 2002
The sphinganine-analog mycotoxins (SAMs) fumonisin B1 and AAL toxins are inhibitors of eukaryotic sphinganine N-acyltransferase in vitro. Treatment of eukaryotes with SAMs generally results in an accumulation of sphingoid base precursors and a depletion ...
Bas F. Brandwagt, Tarcies J. A. Kneppers, H. John J. Nijkamp, Jacques Hille   +3 more
doaj   +1 more source

Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum

Journal of Chromatography B: Biomedical Sciences and Applications, 1998
The fumonisin mycotoxins, which are worldwide contaminants of corn, inhibit de novo sphingolipid biosynthesis leading to elevation in the ratio of the sphingoid bases, sphinganine and sphingosine, in the serum of animals exposed to fumonisins. A new HPLC method for the determination of the ratio of these bases in serum has been developed involving ...
Shephard, Gordon Seymour, van der Westhuizen, L   +1 more
openaire   +3 more sources

Phospholipid Interconversion and Transport Are Altered in Glaucoma

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Genea Edwards, Ruminder Kaur, Anna Mueller, Noël Ziebarth, Richard K. Lee, Sanjoy K. Bhattacharya   +5 more
wiley   +1 more source

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. [PDF]

, 2016
With the passing of Dr. Robert Bittman from pancreatic cancer on the 1st October 2014, the lipid research field lost one of the most influential and significant personalities.
Pyne, Nigel J., Tigyi, Gabor J.
core   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Sphingosine basis in milk

Mljekarstvo, 2006
Sphingolipids are widespread membrane components that are found in all eukaryotic cells. They are defined as compounds having a long-chain sphingoid base as the backbone. The most frequent long-chain bases in most of the mammals are D-erythro-sphinganine
Slavica Ribar, Ivana Karmelić, Marko Mesarić   +2 more
doaj