Results 61 to 70 of about 8,836 (207)

Effects of sphinganine and GT-11 on dihydroceramides, ceramides and cytotoxicity.

, 2013
A-C) CCRF-CEM cells were treated with sphinganine (4 µM, S) ± GT-11 (0.5 µM, G) for six hours and sphingolipids analyzed. A) Total dihydroceramides (DHCer) and ceramides (Cer) were normalized to drug/fatty acid vehicle-treated cells (control) and plotted
Michael W. Holliday Jr. (455894), Barry J. Maurer (455896), Stephen B. Cox (455895), Min H. Kang (175656)   +3 more
core   +1 more source

Fenretinide induces lethal autophagy via a novel ensemble of life and death regulators: dihydroceramide and sphinganine versus sphinganine 1-phosphate

, 2007
Sphingolipids are unique lipids that serve numerous functions important in cell regulation. Some categories of sphingolipids have also been implicated in the mechanism of action of cancer chemotherapeutic drugs, with the hypothesis being that these drugs
Fluke, Katherine Clair
core   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

A highly efficient and versatile synthesis of D- and L-erythro-sphinganine

, 2001
An expedient convergent synthesis of naturally occurring C-18-erythro-sphinganine (dihydrosphingosine, 1) is presented. Chiral protected 2-amino-1,3,4-butanetriol 6 is readily transformed into oxazolinyl oxirane building block 9, which is alkylated by a ...
Sebek, P., Hertweck, C., Svatoš, A.
core   +1 more source

Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity

Critical Care, 2018
Background This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and whether this profile can be used for disease severity assessment.
Pu Ning, Yali Zheng, Qiongzhen Luo, Xiaohui Liu, Yu Kang, Yan Zhang, Rongbao Zhang, Yu Xu, Donghong Yang, Wen Xi, Keqiang Wang, Yusheng Chen, Shuchang An, Zhancheng Gao   +13 more
doaj   +1 more source

Back Cover: Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation (View 4/2026)

VIEW, Volume 7, Issue 4, August 2026.
During influenza virus infection, the secreted metabolite (sphinganine‐phosphate) promotes the proliferation and activation of influenza virus‐specific CD8+ T cells, effectively inhibit virus replication, reduce inflammatory damage, and thus play a protective role in influenza virus infection.
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ration during chronic exposure in ducks

, 2006
International audienceSa and the Sa/So ratio are very sensitive biomarkers of exposure to fumonisins in several species. We previously demonstrated that increases in Sa and in the Sa/So ratio in serum were less pronounced when ducks ingested fumonisins ...
Bénard, G., Tardieu, Delphine, Babile, René, Auvergne, Alain, Tran, Stéphane, Guerre, P., Bailly, J.D.   +6 more
core   +2 more sources

Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice via S1P1 receptor activation

Laboratory Investigation, 2010
Liver failure due to ischemia and reperfusion (IR) and subsequent acute kidney injury are significant clinical problems. We showed previously that liver IR selectively reduced plasma sphinganine-1-phosphate levels without affecting sphingosine-1 ...
S. Park, Mihwa Kim, Sean W. C. Chen, K. Brown, Vivette D. D'Agati, H. Lee   +5 more
semanticscholar   +1 more source

Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS

Lipids in Health and Disease, 2023
Background Stroke is the leading cause of death in humans worldwide, and its incidence increases every year. It is well documented that lipids are closely related to stroke.
Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie, Yingfeng Zhang   +4 more
doaj   +1 more source

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source