Results 131 to 140 of about 48,095 (292)

Plasma Glucosylsphingosine in GBA1 E365K, N409S, and L483P Heterozygous Mutation Carriers

Movement Disorders, EarlyView.
Abstract Background GBA1 encodes the lysosomal enzyme glucocerebrosidase, with key substrates that include glucosylceramide and glucosylsphingosine. The E365K variant is the most common variant in GBA1 that is associated with Parkinson's disease (PD) but is not associated with Gaucher disease.
Julian Agin‐Liebes, Alexander Haimovich, Rachel Griep, Nathan Galen Hatcher, Lihang Yao, Cheryl Waters, Shalini Padmanabhan, Roy N. Alcalay   +7 more
wiley   +1 more source

Probing for Preferential Interactions among Sphingolipids in Bilayer Vesicles Using the Glycolipid Transfer Protein

, 2001
Peter Mattjus, Adam Kline, Helen M. Pike, Julian G. Molotkovsky, Rhoderick E. Brown   +4 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Decision letter: The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

, 2019
Brian Wattenberg, Gerhild van Echten‐Deckert, Roger Sandhoff   +2 more
openalex   +1 more source

Sphingolipids in Inflammation [PDF]

Mediators of Inflammation, 2018
Elisabetta Albi, Alice Alessenko, Sabine Grösch   +2 more
openaire   +3 more sources

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Editorial: Sphingolipid metabolism dysfunction in cancer

Frontiers in Endocrinology, 2023
Rashika El Ridi, Jingjing Duan, Junfei Jin   +2 more
doaj   +1 more source

Metabolomics Reveals Dysregulated Sphingolipid and Amino Acid Metabolism Associated with Chronic Obstructive Pulmonary Disease

, 2022
Jeeyoung Kim, Bharathi Suresh, Myoung Nam Lim, Seok‐Ho Hong, Kye-Seong Kim, Ha Eun Song, Hyo Yeong Lee, Hyun Ju Yoo, Woo Jin Kim   +8 more
openalex   +2 more sources

Plasmodesmata‐located proteins: The molecular hubs in noncell‐autonomous immunity

New Plant Protection, EarlyView.
Plasmodesmata serve as critical battlefields for plant immunity, regulated by diverse proteins. This article provides a comprehensive review of the regulatory mechanisms, challenges, and future directions concerning proteins located within plasmodesmata and their roles in plant defense responses.
Zheng Wu, Xiaoyi Shan
wiley   +1 more source

In Silico Analysis for Sphingolipid Metabolism-Related Genes in Human Kidney Clear Cell Carcinoma Using The Cancer Genome Atlas. [PDF]

, 2020
Woo‐Jae Park, Jee Young Park, Taeg Kyu Kwon, Jong‐Wook Park, Shin Kim   +4 more
openalex   +1 more source