Results 151 to 160 of about 48,095 (292)

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Exploratory Pilot Study on the Serum Ceramide (16:0) to Sphingosine-1-Phosphate Ratio as a Potential Indicator of Lupus Nephritis and Disease Activity. [PDF]

Int J Mol Sci
Kim JW, Kim SH, Baek WY, Jung JY, Kim HA, Suh CH.   +5 more
europepmc   +1 more source

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management

The Journal of Dermatology, EarlyView.
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Takashi Sakai
wiley   +1 more source

Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation. [PDF]

Sci Rep
Rogalska M, Błachnio-Zabielska A, Zabielski P, Janica J, Roszczyc-Owsiejczuk K, Pogodzińska K, Andrzejuk A, Dąbrowski A, Flisiak R, Rogalski P.   +9 more
europepmc   +1 more source

Skin Lipid–Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis

Allergy, EarlyView.
This study investigates mutual interaction of skin microbes and surface lipids in AD using the advanced method of shotgun lipidomics with ultra‐broad coverage of lipids and 16S amplicon sequencing of tape strips taken from lesional and non‐lesional AD and healthy controls.
Madhumita Bhattacharyya, Felix Lauffer, Manja Jargosch, Kristina Frey, Mahsa Shahidi Dadras, Theresa Raunegger, Sophia Wasserer, Carsten B. Schmidt‐Weber, Tilo Biedermann, Kilian Eyerich, Stefanie Eyerich, Claudia Traidl‐Hoffmann, Christian Klose, Matthias Reiger, Natalie Garzorz‐Stark   +14 more
wiley   +1 more source

Sphingolipid-mediated vesiculation in multidrug-resistant <i>Sphingobacterium detergens</i> under polymyxin B stress. [PDF]

Appl Environ Microbiol
Min J, Woo Y, Park Y, Park W.
europepmc   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Sphingolipids in Gaucher disease: a systematic review. [PDF]

Orphanet J Rare Dis
Lake A, Fuller M.
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The Associations of Circulating Sphingolipid Levels with Future Loss of Vibration and Light Pressure Sensation in the Lower Limb. [PDF]

Biomedicines
Barzilay JI, Bartz TM, Longstreth WT, Strotmeyer ES, Hoofnagle AN, Siscovick D, Mukamal KJ, Lemaitre RN.   +7 more
europepmc   +1 more source