Sphingolipids associated research in Alzheimer's disease: an explored trends analysis. [PDF]
Front Aging NeurosciXie MR, Chen YJ, Yuan H.
europepmc +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
From Lysosomal Storage to Neurodegeneration: Sphingolipid Signaling as a Driver of CNS Pathology and Biomarker Strategy in Neuronopathic Gaucher Disease. [PDF]
Int J Mol SciCasazza K, Kartha RV, Jarnes JR.
europepmc +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Editorial: Sphingolipid metabolism dysfunction in cancer
Frontiers in Endocrinology, 2023 Rashika El Ridi +2 more
doaj +1 more source
Intracranial calcifications in DEGS1-Related Leukodystrophy: a potentially under-recognised neuroimaging feature. [PDF]
Neurol SciVaia Y +9 more
europepmc +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
Sphingolipidomic Profiling of Peripheral Blood Mononuclear Cells Reveals a Distinct Immunometabolic Signature Across Patients with Essential Obesity and Metabolic Syndrome Compared to Normal-Weight Healthy Subjects. [PDF]
J Clin MedRigamonti AE +6 more
europepmc +1 more source
Regulation of sphingolipid synthesis via Orm1 and Orm2 in yeast
, 2012 Sphingolipids are critical components of membranes and sphingolipid metabolites also serve as signaling molecules. Yeast Orm1 and Orm2 belong to a conserved family of ER membrane proteins that regulate serine palmitoyltransferase, catalyzing the first ...
Liu, Ming +4 more
core
International Endodontic Journal, EarlyView.ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source