Results 191 to 200 of about 42,593 (240)

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity <i>via</i> the ATF4-SPTLC1 axis. [PDF]

Front Pharmacol
Zhao Y, Li S, Jiang L, Zhao Y, Kuang W, Wei Q, Zhou Y, Han S, Wang L, Li H, Dai Y, Yang X, Xu S, Qin F, Chen R, Chen Y, Liu C, Bu Q, Chen B, Liu B, Qin M, Zhao Y, Cen X.   +22 more
europepmc   +1 more source

Lachnospiraceae‐Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Ischaemic cardiovascular diseases, particularly myocardial infarction (MI), remain the leading causes of morbidity and mortality worldwide. Targeting extracellular vesicles (EVs) from the gut microbiota by diet may provide opportunities to improve cardiovascular health. Barley leaf (BL) has a long history of use in Traditional Chinese medicine
Wenjing Chen, Yifan Zhao, Qian Zhao, Yingzhuo Zhou, Chen Ma, Li Dong, Yinghua Luo, Zhong Zhang, Fang Chen, Xiaosong Hu, Daotong Li   +10 more
wiley   +1 more source

Bovine Parainfluenza Virus Type 3 Infection Reprograms the Bovine Serum Lipidome Associated with Phosphatidylinositol Depletion and Sphingolipid Axis Activation. [PDF]

Microorganisms
Wen S, Zhang J, Lu N, Tian D, Meng L, Gao Z, Song Y.   +6 more
europepmc   +1 more source

Integrated multi-omics reveals population-specific mechanisms of cardiovascular disease in high-altitude environments. [PDF]

iScience
Meng W, Yang J, Wang X, Zhai X, Luo G, Sha Y, Pan H, Xu W, Tong HHY, Lopes Lao EP, Zhong-Ga CR, Cui S, Song X, Li K.   +13 more
europepmc   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Macrophage extracellular traps amplify retinal endothelial anoikis via the S1P-S1PR axis in diabetic retinopathy. [PDF]

J Transl Med
Song Y, Li H, Feng L, Liu G, Wang F, Liao X, Li M.   +6 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis. [PDF]

J Lipid Res
Chiappa NF, Lal N, Botchwey EA.
europepmc   +1 more source

Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge

Molecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.
In this cohort of term and preterm infants, urinary amino acid and acylcarnitine concentrations varied by diabetes in pregnancy exposure and gestational age at birth, and certain patterns of urinary metabolites were differentially related to postnatal adiposity development in preterm infants of women with diabetes in pregnancy. ABSTRACT In infants born
Catherine O. Buck, Sarah McCollum, Weiwei Wang, TuKiet T. Lam, Sarah N. Taylor, Veronika Shabanova   +5 more
wiley   +1 more source

CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis. [PDF]

J Transl Med
Wang Y, Chen X, You G, Yu S, Chen C, Lian R, Diao L, Li Y, Yin T.   +8 more
europepmc   +1 more source