Results 221 to 230 of about 68,956 (338)

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Machine learning-driven prognostic model based on sphingolipid-related gene signature in pancreatic cancer: development and validation. [PDF]

Transl Cancer Res
Zou Q, Jiang H, Sun Q, Peng Q, He J, Xie K, Wei F.   +6 more
europepmc   +1 more source

Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase [PDF]

, 1995
Solly Weiler, John M. Tomich, Yasuo Kishimoto, John S. O'Brien, John A. Barranger   +4 more
openalex   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

Sphingolipid metabolism dysregulation: A cause for lung cancer development, progression, and resistance to therapies. [PDF]

Chin Med J Pulm Crit Care Med
Mao C.
europepmc   +1 more source

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

The FEBS Journal, EarlyView.
Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Altered levels of sphingolipid metabolites in serum of locally advanced rectal cancer patients: A pilot study. [PDF]

J Med Biochem
Bjelanović J, Nikolić A, Aslan M, Miladinov M, Kotur N, Barišić G, Dragicević S.   +6 more
europepmc   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics. [PDF]

Front Pharmacol
Chi P, Zhang H, Chen Y, Xie J, Ayixianmuguli Y, Wu C, Liu M.   +6 more
europepmc   +1 more source

Sphingolipid-enriched Membrane Domains from Rat Cerebellar Granule Cells Differentiated in Culture [PDF]

, 2000
Alessandro Prinetti, Vanna Chigorno, Guido Tettamanti, Sandro Sonnino   +3 more
openalex   +1 more source