Results 231 to 240 of about 52,400 (306)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Multi-omics reveal phosphatidic acid phosphatases modify Niemann-Pick type C disease severity. [PDF]

iScience
Munkacsi AB, Conway GE, Multerer K, Jackson MD, Csaki L, Rajakumar T, Sheridan JP, Niktab E, Hwu WL, Chien YH, Walterfang M, Del Rio Hernandez C, Chan RB, Zhou B, Nandakumar R, Zhang P, Di Paolo G, Maue RA, Reue K, Sturley SL.   +19 more
europepmc   +1 more source

Alzheimer's disease biological domain sub‐stratification enhances the precision of functional analyses

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The Target Enablement to Accelerate Therapy Development for AD (TREAT‐AD) bioinformatics pipeline employs a rank‐and‐organize strategy. Disease‐associated genes drive enrichment of large AD‐linked endophenotypes. However, these biological areas were too large to promote hypothesis development or target identification.
Gregory A. Cary, Sai Sruthi Amirtha Ganesh, Laura Heath, Karina Leal, Martin Kampmann, Frank M. Longo, Robert R. Butler III, Allan L. Levey, Gregory W. Carter, Jesse Wiley   +9 more
wiley   +1 more source

Therapeutic effect of <i>Tripterygium hypoglaucum (H. Lév.) Hutch.</i> extract on psoriasis-like skin inflammation correlated with gut microbiota homeostasis in mice. [PDF]

Front Pharmacol
Wang Z, Cui H, Huang H, Zhang P, Yin L, Luo G, Li Q, Zhang Y, Meng L, Chang W, Li X, Yang X, Ye J.   +12 more
europepmc   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer. [PDF]

J Proteome Res
Babuta J, Gruevska A, Wickremesinghe C, Montoya A, Roumelioti G, Shliaha P, Balcells C, McKinney F, Bray C, Athersuch T, Martin M, Keun H, Hall Z.   +12 more
europepmc   +1 more source

Molecular Insights Into Heat Stress Resilience in Chickpea Near‐Isogenic Lines

Plant, Cell &Environment, Volume 49, Issue 7, Page 4577-4580, July 2026.
Miriam Negussu, Maria Ventimiglia, Chiara Vergata, Matteo Buti, David J. Bonfil, Dudy Bar‐Zvi, Michele Zaccai, Federico Martinelli   +7 more
wiley   +1 more source

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

High-fat diet-driven gut microbial sphingolipid metabolic reprogramming is associated with stress susceptibility in CUMS rats. [PDF]

Front Microbiol
Xian J, Li Y, Feng Z, Jin Y, Cai T, Cao M, Cao Y.   +6 more
europepmc   +1 more source

Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen, Michael R. Duggan, Jigyasha Timsina, Ying Xu, Daniel Western, Katherine Gong, Menghan Liu, John Budde, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Tammie L. S. Benzinger, Brian A. Gordon, Mahdi Moqri, Knight Alzheimer Disease Research Center (Knight‐ADRC), Laura Ibanez, Keenan A. Walker, Carlos Cruchaga, Muhammad Ali   +18 more
wiley   +1 more source