Results 241 to 250 of about 52,400 (306)

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and Tied to Ceramide Homeostasis. [PDF]

FASEB J
Mrkacek M, Tumova M, Puskasu A, Utekal P, Vrbacky M, Kuchar L, Draber P, Bugajev V.   +7 more
europepmc   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

The biological basis of Blood-Heat syndrome in children with Henoch-Schonlein purpura nephritis: a multidimensional analysis based on clinical proteomics and an animal model. [PDF]

Front Pharmacol
Xu S, Xu Y, Bi Y, Ding Y, Zhang X, Xi L, Ren X.   +6 more
europepmc   +1 more source

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 745-755, June 2026.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin, Anuradha U. K. H. Bambarandhage, Michelle Moreno Escalona, Dimitra Ivanova, Tim Gate, Helen Tench, Manfred Beckman, Helen Phillips, Mandana Pennick, Luis A. J. Mur   +9 more
wiley   +1 more source

Triiodothyronine-driven pro-inflammatory responses of dendritic cells are restrained by sphingolipid signaling. [PDF]

J Endocrinol
Negretti-Borga DM, Pires Teixeira M, Blanco A, Puentes EN, Soler MF, Alamino VA, Donadio AC, Clarke CJ, Montesinos MDM, Hannun YA, Pellizas CG.   +10 more
europepmc   +1 more source

Case Report of Dual Variants in SLC1A4 and APOE: A Possible Link Between Amino Acid and Lipid Metabolism

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) is a rare autosomal recessive neurodevelopmental disorder linked to biallelic variants in the SLC1A4 gene, which encodes the ASCT1 amino acid transporter critical for neutral amino acid uptake in neurons.
Mohammed Qaisiya, Kenana Altell, Wasef Alhroub, Mahmoud Ramlawe, Elisabetta Battocchio, Fabrizia Guarnieri, Mu'taz Altamimi   +6 more
wiley   +1 more source

Predictive epigenetic biomarkers of successful weight-loss intervention in pre-pubertal children with obesity. [PDF]

Clin Epigenetics
Palmieri F, Castellano-Escuder P, Parra-Vargas M, Leal-Witt MJ, Krauel MR, Lerin C, Perera A, Jiménez-Chillarón JC.   +7 more
europepmc   +1 more source

Ceramide‐mediated mitochondrial dysfunction in nonobese nonalcoholic fatty liver disease: A regulatory role for serine palmitoyltransferase subunit 2

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Serine palmitoyltransferase long chain base subunit 2 (Sptlc2) promotes ceramide‐associated mitochondrial dysfunction in nonobese nonalcoholic fatty liver disease (NAFLD). A dry‐fried soybean‐induced nonobese NAFLD model shows Sptlc2 upregulation, ceramide accumulation, and mitochondrial dysfunction.
Li‐Jun Xue, Guang‐Yan Yao, Fei‐Fei Fan, Kai‐Min Li, Wen‐Ming Wu   +4 more
wiley   +1 more source

Structural and functional dissection of a higher-order oligomerization interface in yeast ceramide synthase. [PDF]

Nat Commun
Fang Q, Yang C, Yao N, Xie T, Gong X.
europepmc   +1 more source