Results 121 to 130 of about 1,665,622 (222)

Sphingolipid metabolism and hematologic disorders: current understanding and future directions. [PDF]

Front Physiol
Kuang Z, Huang T, Chen G.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Human Milk Oligosaccharide LNnT Attenuates Colonic Barrier Dysfunction and Associated Cognitive Impairment via Modulating Sphingolipid Metabolism and Gut Microbiota. [PDF]

Molecules
Wang M, Zhu L, Liao J, Bao L, Li H, Deng Z, Li J, Zheng L, Zhang B.   +8 more
europepmc   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu, Zhenyang Xu, Chenli Su, Yanqian Zhao, Linjing Qiang, Xiayong Jing, Yuxiang Sun   +6 more
wiley   +1 more source

Combined transcriptomic and lipidomic analysis reveals enhanced lipogenesis in memory Tregs upon TCR activation. [PDF]

Immunohorizons
Sato Y.
europepmc   +1 more source

Fisetin Attenuates Uterine Leiomyoma in Rats: Potential Crosstalk Between HMGB1, SphK1/S1P, and TGF‐β Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Fisetin attenuates monosodium glutamate‐induced uterine leiomyoma by reducing sex hormones and suppressing S1P/SphK1 signaling, HMGB1‐mediated inflammation, and fibrotic markers. These coordinated effects alleviate fibrosis and restore uterine tissue architecture, highlighting fisetin as a promising natural therapeutic candidate.
Nashwa Maghraby, Esraa Khalaf, Marwa T. Hussien, Ahmed M. A. Sobh, Nagla T. Elmelegy   +4 more
wiley   +1 more source

Inhibition of acid sphingomyelinase links sphingolipid remodeling to necroptotic cell death. [PDF]

RSC Chem Biol
Pilapil LAE, Chitkara S, Atilla-Gokcumen GE.   +2 more
europepmc   +1 more source

ALY688 Protects Against Myocardial Ischemia‐Reperfusion Injury via Direct Effects and Rab8a‐Dependent Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
This study identifies ALY688, a synthetic adiponectin receptor agonist, as a potent cardioprotective agent against ischemia‐reperfusion injury. ALY688 reduced infarct size, cardiomyocyte death, and oxidative stress, while preserving cardiac function. Mechanistically, it enhanced extracellular vesicle (EV) number through Rab8a‐dependent signaling and ...
Hye Kyoung Sung, Jialing Tang, Yubin Lei, Khang Nguyen, Eddie Tam, Jun Wu, Ren‐Ke Li, Vincent Richard, Christoph H. Borchers, Lina Antounians, Dylan Burger, Augusto Zani, Gary Sweeney   +12 more
wiley   +1 more source

Sphingolipid-Neuroinflammation Axis in Parkinson's Disease: Focus on S1P/SPHK1-NF‑κB Signaling. [PDF]

J Inflamm Res
Kong X, Wang H, Dong J, Cheng X, Wei J.
europepmc   +1 more source

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Johann Mar Gudbergsson, Pedro Henrique Gobira, Rodrigo Grassi‐Oliveira, Anders Etzerodt   +3 more
wiley   +1 more source