Results 121 to 130 of about 851,389 (262)

System level modeling and analysis of TNF-α mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets. [PDF]

Front Physiol, 2022
Banaras S, Paracha RZ, Nisar M, Arif A, Ahmad J, Tariq Saeed M, Mustansar Z, Shuja MN, Paracha RN.   +8 more
europepmc   +1 more source

Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation

, 2017
Chronic inflammation is a common underlying factor in many major metabolic diseases afflicting Western societies. Sphingolipid metabolism is pivotal in the regulation of inflammatory signaling pathways.
Christopher Blesso, Gregory Norris
core   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Determinants of C₁₆-Ceramide Binding to p53

Biomolecules
The tumor suppressor p53 coordinates cellular stress responses, but underlying mechanisms remain incompletely understood. We previously demonstrated that, in response to metabolic stress, C16-ceramide produced by ceramide synthase 6 (CerS6) directly ...
Madeline S. Childress, Kristen A. Jeffries, Sergey A. Krupenko, Natalia I. Krupenko   +3 more
doaj   +1 more source

Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving Aβ. [PDF]

Evid Based Complement Alternat Med, 2021
Lin H, Wu S, Weng Z, Wang H, Shi R, Tian M, Wang Y, He H, Wang Y, Liu X, Jian Z, Wei F, Wang P, Zhang L, Liu Y, Guo Q, Chen C, Yang W.   +17 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling. [PDF]

Sci Rep, 2022
Devarakonda T, Valle Raleigh J, Mauro AG, Lambert JM, Cowart LA, Salloum FN.   +5 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source

Development of a Novel Sphingolipid Signaling Pathway-Related Risk Assessment Model to Predict Prognosis in Kidney Renal Clear Cell Carcinoma. [PDF]

Front Cell Dev Biol, 2022
Sun Y, Xu Y, Che X, Wu G.
europepmc   +1 more source