Results 41 to 50 of about 66,876 (325)

Exploring Sphingolipid Implications in Neurodegeneration

Frontiers in Neurology, 2020
Over the past decade, it was found that relatively simple sphingolipids, such as ceramide, sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in neuronal functions by regulating rates of neuronal growth and differentiation ...
Alice V. Alessenko, Elisabetta Albi
doaj   +1 more source

Dietary Fat and Protein Intake in Relation to Plasma Sphingolipids as Determined by a Large-Scale Lipidomic Analysis

Metabolites, 2021
Sphingolipid concentrations have been associated with risk of type 2 diabetes and cardiovascular diseases. Because sphingolipids can be synthesized de novo from saturated fatty acids (SFA), dietary fatty acids may affect plasma sphingolipid ...
Jowy Yi Hoong Seah, Wee Siong Chew, Federico Torta, Chin Meng Khoo, Markus R. Wenk, Deron R. Herr, E. Shyong Tai, Rob M. van Dam   +7 more
doaj   +1 more source

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]

, 2003
Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik, Heinecke, Karie, Mendel, Jane, Saba, Julie D.   +3 more
core   +1 more source

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 ProductionSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells ...
Bin Bao, Youyuan Wang, Pavl Boudreau, Xinyang Song, Meng Wu, Xi Chen, Izabel Patik, Ying Tang, Jodie Ouahed, Amit Ringel, Jared Barends, Chuan Wu, Emily Balskus, Jay Thiagarajah, Jian Liu, Michael R. Wessels, Wayne Isaac Lencer, Dennis L. Kasper, Dingding An, Bruce Harold Horwitz, Scott B. Snapper   +20 more
doaj   +1 more source

A Simulation Study on Multicomponent Lipid Bilayer

, 2005
Simulation of a multicomponent lipid bilayer having a fixed percentage of cholesterol is done to study phase transition leading to domain formation.
Anderson, Anderson, Banerjee, Banerjee, Ben-Shaul, Bloom, Brown, Brown, Brown, de Miguel, Doniach, Ermoshkin, Evans, Ferrenberg, Harrison, Jacobson, Jayashree Saha, Lee, May, Mouritsen, Nielsen, Nielsen, Radhakrishnan, Sabra, Scherfeld, Simons, Simons, Srilekha Banerjee, Zhang   +28 more
core   +1 more source

Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. [PDF]

, 2017
Membrane contact sites (MCSs) function to facilitate the formation of membrane domains composed of specialized lipids, proteins, and nucleic acids. In cells, membrane domains regulate membrane dynamics and biochemical and signaling pathways.
Murley, Andrew, Niles, Bradley J, Nunnari, Jodi, Powers, Ted, Prinz, William A, Toulmay, Alexandre, Yamada, Justin   +6 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Plasma sphingolipids mediate the association between gut microbiome composition and type 2 diabetes risk in the HELIUS cohort: a case-cohort study

BMJ Open Diabetes Research & Care
Introduction The association between the gut microbiome and incident type 2 diabetes (T2D) is potentially partly mediated through sphingolipids, however these possible mediating mechanisms have not been investigated.
Femke Rutters, Max Nieuwdorp, Mirthe Muilwijk, Irene van Valkengoed, Bert-Jan van den Born, Henrike Galenkamp, Joline W J Beulens, Martin F Overbeek, Mark Davids   +8 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Diverse Facets of Sphingolipid Involvement in Bacterial Infections

Frontiers in Cell and Developmental Biology, 2019
Sphingolipids are constituents of the cell membrane that perform various tasks as structural elements and signaling molecules, in addition to regulating many important cellular processes, such as apoptosis and autophagy.
Tobias C. Kunz, Vera Kozjak-Pavlovic
doaj   +1 more source