Results 61 to 70 of about 41,788 (297)
Plant sphingolipids: Their importance in cellular organization and adaption [PDF]
, 2016 Sphingolipids and their phosphorylated derivatives are ubiquitous bio-active components of cells. They are structural elements in the lipid bilayer and contribute to the dynamic nature of the membrane. They have been implicated in many cellular processes
Michaelson, Louise V. +8 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Sphingolipids: the nexus between Gaucher disease and insulin resistance
Lipids in Health and Disease, 2010 Sphingolipids constitute a diverse array of lipids in which fatty acids are linked through amide bonds to a long-chain base, and, structurally, they form the building blocks of eukaryotic membranes.
Fuller Maria
doaj +1 more source
Investigations of the health benefits of buttermilk fat globule membrane lipid components [PDF]
, 2011 The milk fat globule membrane (MFGM) that surrounds fat globules in milk is a natural source of sphingolipids, phoshpholipids and proteins with defined anticancer properties.
Kuchta, Anna
core
Neurodegenerative Disorders: Spotlight on Sphingolipids
, 2021 Neurodegenerative diseases are incurable diseases of the nervous system that lead to a progressive loss of brain areas and neuronal subtypes, which is associated with an increase in symptoms that can be linked to the affected brain areas.
Melissa Vos, Frida Mandik
core +1 more source
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway
FEBS Letters, 2022 Modern cell membranes contain a bewildering complexity of lipids, among them sphingolipids (SLs). Advances in mass spectrometry have led to the realization that the number and combinatorial complexity of lipids, including SLs, is much greater than previously appreciated.
Tania C. B. Santos +2 more
openaire +2 more sources
Advanced Science, EarlyView.Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu +11 more
wiley +1 more source
Regulation of epidermal sphingolipid synthesis by permeability barrier function.
Journal of Lipid Research, 1991 A mixture of sphingolipids, cholesterol, and free fatty acids forms the intercellular membrane bilayers of the stratum corneum which are presumed to regulate epidermal barrier function.
WM Holleran +5 more
doaj +1 more source
Sphingolipids in the Heart: From Cradle to Grave
Frontiers in Endocrinology, 2020 Cardiovascular diseases are the leading cause of mortality worldwide and this has largely been driven by the increase in metabolic disease in recent decades.
Anna Kovilakath +3 more
doaj +1 more source
Advanced Science, EarlyView.In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li +10 more
wiley +1 more source