Results 41 to 50 of about 45,038 (292)

Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling*

Journal of Lipid Research, 2008
Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus.
Robert W. Ledeen, Gusheng Wu
doaj   +1 more source

Biophysical and biological properties of atypical sphingolipids : implications to physiology and pathophysiology

, 2021
1-deoxy-sphingolipids lack the C1-OH on their sphingoid base and present a cis ∆14-15 double bond instead of the canonical trans ∆4-5 double bond. Increased 1-deoxy-sphingolipid levels are directly correlated with the development and progression of ...
Da Cunha Branco Dos Santos, Tânia
core  

Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae" [PDF]

, 2006
sphingoid base, one of the intermediate of sphingolipids metabolites, plays a key role as a signaling molecule which activate PKH kinases and its substrates YPKs and PKC1 (Casamayor, Torrance et al. 1999; Friant, Lombardi et al.
Shioda, Ryo
core   +1 more source

Exploring Sphingolipid Implications in Neurodegeneration

Frontiers in Neurology, 2020
Over the past decade, it was found that relatively simple sphingolipids, such as ceramide, sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in neuronal functions by regulating rates of neuronal growth and differentiation ...
Alice V. Alessenko, Elisabetta Albi
doaj   +1 more source

A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells

Biophysica, 2023
In recent years, sphingolipids have attracted significant attention due to their pivotal role in cellular functions and physiological diseases.
Bahar Faramarzi, Martina Moggio, Nadia Diano, Marianna Portaccio, Maria Lepore   +4 more
doaj   +1 more source

Cardiomyocytes, sphingolipids and cardio myotoxicity

, 2023
Purpose of reviewSphingolipids are structurally diverse membrane lipids localized in lipid bilayers. Sphingolipids are not only important structural components of cellular membranes, but they are also important regulators of cellular trafficking and ...
Borén, Jan,, Levin, Malin,, Linda Andersson, Andersson, Linda,, Malin C Levin, Jan Borén   +5 more
core   +1 more source

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 ProductionSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells ...
Bin Bao, Youyuan Wang, Pavl Boudreau, Xinyang Song, Meng Wu, Xi Chen, Izabel Patik, Ying Tang, Jodie Ouahed, Amit Ringel, Jared Barends, Chuan Wu, Emily Balskus, Jay Thiagarajah, Jian Liu, Michael R. Wessels, Wayne Isaac Lencer, Dennis L. Kasper, Dingding An, Bruce Harold Horwitz, Scott B. Snapper   +20 more
doaj   +1 more source

The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]

, 2012
Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Trumel, Catherine, Schatzmayr, Gerd, Loureiro-Bracarense, Ana-Paula, Cossalter, Anne-Marie, Oswald, Isabelle P., Cossalter, Anne Marie, Grenier, Bertrand, Moll, Wulf-Dieter, Oswald, Isabelle P, Schwartz, Heidi-Elisabeth, Kolf-Clauw, Martine, Schwartz, Heidi Elisabeth, Bracarense, Ana-Paula   +12 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Plasma sphingolipids mediate the association between gut microbiome composition and type 2 diabetes risk in the HELIUS cohort: a case-cohort study

BMJ Open Diabetes Research & Care
Introduction The association between the gut microbiome and incident type 2 diabetes (T2D) is potentially partly mediated through sphingolipids, however these possible mediating mechanisms have not been investigated.
Femke Rutters, Max Nieuwdorp, Mirthe Muilwijk, Irene van Valkengoed, Bert-Jan van den Born, Henrike Galenkamp, Joline W J Beulens, Martin F Overbeek, Mark Davids   +8 more
doaj   +1 more source