Results 101 to 110 of about 52,176 (275)

Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults

Nutrition & Diabetes, 2014
Objective:Recent studies indicate that sphingolipids, sphingomyelin (SM) and ceramide (Cer) are associated with the development of metabolic syndrome.
H. Hanamatsu, Shunsuke Ohnishi, S. Sakai, K. Yuyama, S. Mitsutake, Hiroshi Takeda, S. Hashino, Y. Igarashi   +7 more
semanticscholar   +1 more source

Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) in phospholipid membranes promote α‐synuclein binding, aggregation, and toxicity ...
Finula I. Isik, YuHong Fu, Russell Pickford, Qi Cheng, Yue Yang, Simon J.G. Lewis, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim   +8 more
wiley   +1 more source

Biallelic ELOVL1 Variants Are Linked to Hypomyelinating Leukodystrophy, Movement Disorder, and Ichthyosis

Movement Disorders, EarlyView.
Abstract Background Very long chain fatty acids (VLCFAs) are an integral component of myelin and the epidermal water barrier. Variants in genes encoding enzymes responsible for catalyzing the first and rate limiting step in the production of VLCFAs, elongation of VLCFAs (ELOVLs), underlie a novel group of metabolic disorders. Objectives The goal was to
Keit Men Wong, Reza Maroofian, Kolja Meier, Susann Diegmann, Tinatin Tkemaladze, Javeria Raza Alvi, Behnoosh Tasharrofi, Stephanie Efthymiou, Alexander Munchau, G. Christoph Korenke, Naif Almontashiri, Wafaa Eyaid, Amna Kashgari, Modhi Alotaibi, Jutta Gärtner, Brenda Huppke, Mostafa Asadollahi, Gocha Chikvinidze, Mohammad Keramatipour, Tipu Sultan, Holger Thiele, Peter Nürnberg, Markus H. Gräler, Henry Houlden, Peter Huppke   +24 more
wiley   +1 more source

Tracking Cholesterol/Sphingomyelin-Rich Membrane Domains with the Ostreolysin A-mCherry Protein

PLoS ONE, 2014
Ostreolysin A (OlyA) is an ∼15-kDa protein that has been shown to bind selectively to membranes rich in cholesterol and sphingomyelin. In this study, we investigated whether OlyA fluorescently tagged at the C-terminal with mCherry (OlyA-mCherry) labels ...
Matej Skočaj, Nataša Resnik, Maja Grundner, K. Ota, Nejc Rojko, V. Hodnik, G. Anderluh, A. Sobota, P. Maček, P. Veranič, K. Sepčič   +10 more
semanticscholar   +1 more source

The Occurrence of Cephalin, Sphingomyelin, and Lysolecithin in Bile. [PDF]

, 1960
Fumio Nakayama, Rolf Blomstrand, Arne Kjekshus, Rune Söderquist   +3 more
openalex   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Impact of Nutrition on Sphingolipid‐Regulated Physiology: A Review

Molecular Nutrition &Food Research, EarlyView.
Sphingolipids (SLs) play a role in multiple, if not all physiological processes. This review summarizes the current knowledge on SLs and their role in (patho‐) physiological processes with special regard to dietary and transgenerational effects. Image was created with BioRender.com.
Jonas Voß, Thorsten Hornemann, Bengt‐Frederik Belgardt   +2 more
wiley   +1 more source

Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans

Journal of Lipid Research
Multiple isozymes are encoded in the Caenorhabditis elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase liquid
Hui Luo, Xue Zhao, Zi-Dan Wang, Gang Wu, Yu Xia, Meng-Qiu Dong, Yan Ma   +6 more
doaj   +1 more source

Laboratory assessment of fetal lung maturity: lecithin/sphingomyelin ratio vs. cortisol and foam-test assays. [PDF]

, 1977
Daisy S. McCann, L S Kirkish, Murray L. Barclay, Abbe J. Blair   +3 more
openalex   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source