Results 101 to 110 of about 50,283 (222)

Review and targeted lipidomic biomarkers in atherosclerosis

Российский кардиологический журнал
Ischemic cardiovascular events (ischemic stroke, myocardial infarction) are the most common complications of cardiovascular diseases. One of the leading mechanisms of these complications is atherosclerosis.
A. A. Lomonosova, D. G. Gognieva, M. G. Abdullaev, A. S. Kostikova, N. N. Eroshchenko, A. A. Nartova, A. S. Silantyev, A. Yu. Suvorov, R. N. Komarov, A. N. Dzyundzya, D. Yu. Shchekochikhin, E. A. Syrkina, F. Yu. Kopylov   +12 more
doaj   +1 more source

Sphingomyelin [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Urinary lipid metabolites and progression of kidney disease in individuals with type 2 diabetes

Frontiers in Endocrinology
ObjectiveA substantial proportion of individuals with type 2 diabetes (T2D) experience a fast decline (FD) in kidney function, a high-risk phenotype not reliably identified by current clinical markers.
Yu Xiao, Caifeng Shi, Songyan Qin, Aiqin He, Xiaomei Wu, Chunsun Dai, Yang Zhou   +6 more
doaj   +1 more source

Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Nutritional weight‐loss interventions are known to reduce bone mineral density (BMD), which can be prevented by adding (resistance) exercise training. However, this combined effect is not well studied in non‐obese adults. In addition, the association between biomarkers and metabolite‐based composite health markers with changes in ...
F. A. Bogaards, Inge Groenendijk, Thies Gehrmann, Marian Beekman, Nico Lakenberg, H. Eka D. Suchiman, Lisette C. P. G. M. de Groot, Marcel J. T. Reinders, P. Eline Slagboom   +8 more
wiley   +1 more source

Sphingomyelin regulates astrocyte activity by regulating NF-κB signaling via HDAC1/3 expression

Journal of Lipid Research
Astrocytes comprise approximately 40% of CNS cells and have pivotal roles in brain functions. Under steady-state conditions, astrocytes maintain homeostasis in the CNS through the uptake or release of neurotransmitters.
Ryo Kadowaki, Hana Hirose, Gai Takimoto, Takafumi Kohama, Hiroyuki Nakamura   +4 more
doaj   +1 more source

Differential Gene Expression in Human Hippocampus With Aging

Aging Cell, Volume 25, Issue 4, April 2026.
2 complementary analysis from a transcriptome study in human hippocampal samples of different ages revealed a set of genes differentially expressed in aged individuals linked to inflammation and immune system pathways, DNA repair (RAD23) or neural activity.
Ander Saenz‐Antoñanzas, Manuel Moreno‐Valladares, Maider Muñoz‐Culla, Sara Cruces‐Salguero, Jon Landa, Ainhoa Alberro, Jhonatan Vergara‐Arce, Marta Arroyo‐Izaga, David Otaegui, Ander Matheu   +9 more
wiley   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Targeting Cellular Lipid Rafts for Dynamic Nuclear Polarization Nuclear Magnetic Resonance

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Illuminating lipid rafts within intact cells using dynamic nuclear polarization (DNP). Targeting lipid rafts with the protein ostreolysin A allows the selective delivery of DNP‐compatible radicals, generating hyperpolarization of nuclear spins in the lipid raft. Lipid rafts serve as important platforms for membrane and signaling proteins.
Sarah A. Overall, Agnes Eck, Ancy T. Wilson, Dorothea Pinotsi, Sina J. Hartmann, Katja Packebusch, Snorri Th. Sigurdsson, Alexander B. Barnes   +7 more
wiley   +1 more source

Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles

ChemPhysChem, Volume 27, Issue 5, 13 March 2026.
Biophysical properties of extracellular vesicles (EVs) reflect their composition and membrane organization. We introduce a novel approach using time‐resolved emission spectra (TRES) phasor analysis of the polarity‐sensitive probe Laurdan to characterize membranes with complex compositions.
Petra Riegerová, Mariana Amaro, Peter Kapusta, Antonín Vlček, Martin Smolko, Karel Souček, Vendula Pospíchalová, Martin Hof, Šárka Pokorná   +8 more
wiley   +1 more source