Results 41 to 50 of about 51,735 (168)

Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

Cell Communication and Signaling, 2022
Plain English summary Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells ...
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri   +3 more
doaj   +1 more source

Relationship Between Plasma Acid Sphingomyelinase and Alteration in Taste and Smell as Indicator of Long COVID in Pregnant Women

Reports
Background: Persistent alterations in taste and smell affect a significant proportion of individuals following COVID-19, representing a component of post-acute COVID-19 syndrome, commonly referred to as long COVID.
Federico Fiorani, Giulia Moretti, Laura Cerquiglini, Chiara Gizzi, Giulia Gizzi, Paola Signorelli, Samuela Cataldi, Tommaso Beccari, Elisa Delvecchio, Claudia Mazzeschi, Stefania Troiani, Elisabetta Albi   +11 more
doaj   +1 more source

Quantification of major classes of Xenopus phospholipids by high performance liquid chromatography with evaporative light scattering detection

Journal of Lipid Research, 2000
Lipid signaling has become a major research area of cell biology and there is a need for methods that accurately and easily measure substrates and products of lipases involved in cell signaling.
Bradley J. Stith, Jennifer Hall, Patrick Ayres, Leslie Waggoner, Jeff D. Moore, Walt A. Shaw   +5 more
doaj   +1 more source

Visualizing sphingomyelin in the retina

Experimental Eye Research
Sphingomyelin (SM) is a major component of cellular membranes that is altered by retinal and optic nerve degenerations. However, our understanding of the influence of SM during degenerations is hampered by methodological limitations. Prior investigations have demonstrated the accumulation of SM to plasma membranes of cultured cells, using an enhanced ...
Cassandra Warden, Dalton Raymond, Alex Sanchez, Mathew Seidel, Michael L. Risner   +4 more
openaire   +2 more sources

Interaction of cholesterol with sphingosine

Journal of Lipid Research, 2005
Molecular associations between sphingomyelin and cholesterol provide a molecular basis for the colocalization of these lipids in plasma membrane microdomains (lipid rafts) and for the inhibitory effect of sphingomyelin on the intestinal absorption of ...
Nicolas Garmy, Nadira Taïeb, Nouara Yahi, Jacques Fantini   +3 more
doaj   +1 more source

Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid

Journal of Lipid Research, 1972
Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically exmined.
Pierre Morell, Peter Braun
doaj   +1 more source

Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans

Journal of Lipid Research
Multiple isozymes are encoded in the Caenorhabditis elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase liquid
Hui Luo, Xue Zhao, Zi-Dan Wang, Gang Wu, Yu Xia, Meng-Qiu Dong, Yan Ma   +6 more
doaj   +1 more source

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

Journal of Biological Chemistry, 1994
Sphingomyelin (SM) is a membrane phosphosphingolipid that has recently been identified as a key component of the SM cycle. In this signal transduction pathway, extracellular inducers such as tumor necrosis factor alpha cause hydrolysis of membrane SM, resulting in the generation of the lipid second messenger ceramide. Only 10-20% of cellular SM appears
C M, Linardic, Y A, Hannun
openaire   +2 more sources

Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation.

Journal of Lipid Research, 1996
The sphingomyelin pathway is an important signal transduction system regulating various cellular functions. However, little is known about the effect of sphingomyelin metabolites on vasomotor function.
T Murohara, K Kugiyama, M Ohgushi, S Sugiyama, Y Ohta, H Yasue   +5 more
doaj   +1 more source

Separation of molecular species of sphingomyelin by reversed-phase high-performance liquid chromatography.

Journal of Lipid Research, 1979
A convenient method for the separation of molecular species of sphingomyelin by reversed-phase high-performance liquid chromatography (HPLC) is described.
F B Jungalwala, V Hayssen, J M Pasquini, R H McCluer   +3 more
doaj   +1 more source