Results 31 to 40 of about 78,947 (270)
Upregulation of sphingomyelin and ABCA8 in response to TDP-43 pathology in amyotrophic lateral sclerosis brain. [PDF]
Brain PatholIncreases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Isik FI +4 more
europepmc +2 more sources
The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]
, 2007 Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu +2 more
core +2 more sources
Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs [PDF]
Journal of Cell Biology, 2017 Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of suitable fluorescent SM analogs.
Masanao Kinoshita +12 more
openaire +2 more sources
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
Journal of Lipid Research, 1995 In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj +1 more source
Molecules, 2022 Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was ...
Yejin Ahn +4 more
doaj +1 more source
The Multigenic Sphingomyelin Synthase Family [PDF]
Journal of Biological Chemistry, 2006 Sphingomyelin (SM)3 is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production involves the enzymatic transfer of a phosphocholine head group fromphosphatidylcholine to ceramide, yielding diacylglycerol in the process.
Geta Tafesse, F. +2 more
openaire +4 more sources
Cells, 2022 The biomarkers of Parkinson’s disease (PD) remain to be investigated. This work aimed to identify blood biomarkers for PD using targeted metabolomics analysis.
Kuo-Hsuan Chang +5 more
doaj +1 more source
Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling [PDF]
, 2015 © 2015 Mitchell et al. Abstract Background: Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents ...
Clench, Malcolm +4 more
core +2 more sources
Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status
Frontiers in Endocrinology, 2018 Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus.
Elin Rebecka Carlsson +3 more
doaj +1 more source
Manipulation of lipid rafts in neuronal cells [PDF]
, 2010 Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core +1 more source