Results 31 to 40 of about 51,484 (237)

Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice

Molecules, 2022
Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was ...
Yejin Ahn, Min Guk Kim, Kyungae Jo, Ki-Bae Hong, Hyung Joo Suh   +4 more
doaj   +1 more source

Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson’s Disease

Cells, 2022
The biomarkers of Parkinson’s disease (PD) remain to be investigated. This work aimed to identify blood biomarkers for PD using targeted metabolomics analysis.
Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen   +5 more
doaj   +1 more source

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

Frontiers in Endocrinology, 2018
Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus.
Elin Rebecka Carlsson, Josefine Liv Gilling Grundtvig, Sten Madsbad, Mogens Fenger   +3 more
doaj   +1 more source

Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A2

Journal of Lipid Research, 2000
Modulation of cytosolic phospholipase A2 (cPLA2) activity by sphingomyelin (SPH), ceramide (Cer), and cholesterol (Chol) was investigated in CHO-2B cells activated by the calcium ionophore A23187 and epinephrine.
Elsa Klapisz, Joëlle Masliah, Gilbert Béréziat, Claude Wolf, Kamen S. Koumanov   +4 more
doaj   +1 more source

Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids

Journal of Lipid Research, 2020
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has ...
Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman   +7 more
doaj   +1 more source

The Multigenic Sphingomyelin Synthase Family [PDF]

Journal of Biological Chemistry, 2006
Sphingomyelin (SM)3 is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production involves the enzymatic transfer of a phosphocholine head group fromphosphatidylcholine to ceramide, yielding diacylglycerol in the process.
Geta Tafesse, F., Ternes, P.G., Holthuis, J.C.M.   +2 more
openaire   +4 more sources

The impact of sphingomyelin on the pathophysiology and treatment response to olipudase alfa in acid sphingomyelinase deficiency

Genetics in Medicine Open
Acid sphingomyelinase deficiency (ASMD) is a rare progressive genetic disorder caused by pathogenic variants in the SMPD1 gene causing low or absent activity of the enzyme acid sphingomyelinase, resulting in subsequent accumulation of its substrate ...
Monica Kumar, Mario Aguiar, Andreas Jessel, Beth L. Thurberg, Lisa Underhill, Holly Wong, Kelly George, Vanessa Davidson, Edward H. Schuchman   +8 more
doaj   +1 more source

Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis

Journal of Lipid Research
Adipogenesis is one of the major mechanisms for adipose tissue expansion, during which spindle-shaped mesenchymal stem cells commit to the fate of adipocyte precursors and differentiate into round-shaped fat-laden adipocytes.
Detian Hu, Houyu Zhang, Zhen Liu, Carlos F. Ibáñez, Cai Tie, Meng Xie   +5 more
doaj   +1 more source

Quantitative analysis of ceramide molecular species by high performance liquid chromatography

Journal of Lipid Research, 1998
A method was developed for quantitative analysis of molecular species of ceramide (N-acyl-sphingosine) and dihydroceramide (N-acyl sphinganine) by high performance liquid chromatography (HPLC).
Midori Yano, Etsu Kishida, Yuka Muneyuki, Yasuo Masuzawa   +3 more
doaj   +1 more source

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S]

Journal of Lipid Research, 2020
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases.
Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro   +11 more
doaj   +1 more source