Results 11 to 20 of about 62,442 (260)

Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
Tissue injury in inflammation involves the release of several cytokines that activate sphingomyelinases and generate ceramide. In the lung, the impaired metabolism of surfactant phosphatidylcholine (PC) accompanies this acute and chronic injury. These effects are long-lived and extend beyond the time frame over which tumor necrosis factor (TNF)-α and ...
J, Vivekananda, D, Smith, R J, King
openaire   +3 more sources

Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis

Journal of Lipid Research
Adipogenesis is one of the major mechanisms for adipose tissue expansion, during which spindle-shaped mesenchymal stem cells commit to the fate of adipocyte precursors and differentiate into round-shaped fat-laden adipocytes.
Detian Hu, Houyu Zhang, Zhen Liu, Carlos F. Ibáñez, Cai Tie, Meng Xie   +5 more
doaj   +2 more sources

Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy [PDF]

Nature Communications
Sphingomyelin is a key molecule of sphingolipid metabolism, and its enzymatic breakdown is associated with various infectious diseases. Here, we introduce trifunctional sphingomyelin derivatives that enable the visualization of sphingomyelin distribution
Marcel Rühling, Louise Kersting, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, Dominic A. Helmerich, Tom Pfeuffer, Robin Elflein, Christian Kappe, Markus Sauer, Christoph Arenz, Burkhard Kleuser, Thomas Rudel, Martin Fraunholz, Jürgen Seibel   +14 more
doaj   +4 more sources

Ciliary Membrane Lipid Homeostasis in Health and Disease. [PDF]

Adv Sci (Weinh)
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Huang Z, Liu YY, Sun H, Liu P.
europepmc   +2 more sources

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

Tales and mysteries of the enigmatic sphingomyelin synthase family [PDF]

, 2010
In the last five years tremendous progress has been made toward the understanding of the mechanisms that govern sphingomyelin (SM) synthesis in animal cells.
Chiara Luberto, Sub Membrane Enzymology begr. 01-06-12, Luberto, C., Holthuis, J.C.M., Membrane Enzymology, Joost C. M. Holthuis   +5 more
core   +1 more source

Membrane properties of sphingomyelins [PDF]

FEBS Letters, 2002
Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
openaire   +2 more sources

Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis [PDF]

, 2022
BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue factor) procoagulant activity. The current study was performed to investigate how alterations to sphingomyelin metabolic pathway would affect TF ...
Das, Kaushik, Wang, Jue, Rao, L. Vijaya Mohan, Jiang, Xian-Cheng, Keshava, Shiva, Pendurthi, Usha R., Kolesnick, Richard   +6 more
core   +3 more sources

Sphingomyelin Lipidosis in a Cat [PDF]

Veterinary Pathology, 1987
A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times
H J, Baker, P A, Wood, D A, Wenger, S U, Walkley, K, Inui, T, Kudoh, M C, Rattazzi, B L, Riddle   +7 more
openaire   +2 more sources

Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism

The EuroBiotech Journal, 2017
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Cataldi Samuela, Lazzarini Andrea, Codini Michela, Cascianelli Giacomo, Floridi Alessandro, Bartoccini Elisa, Ceccarini Maria Rachele, Ambesi-Impiombato Francesco Saverio, Beccari Tommaso, Curcio Francesco, Albi Elisabetta   +10 more
doaj   +1 more source