Results 11 to 20 of about 51,484 (237)
The Multiple Roles of Sphingomyelin in Parkinson’s Disease
Biomolecules, 2021 Advances over the past decade have improved our understanding of the role of sphingolipid in the onset and progression of Parkinson’s disease. Much attention has been paid to ceramide derived molecules, especially glucocerebroside, and little on ...
Paola Signorelli +2 more
exaly +3 more sources
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
eLife, 2022 Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway.
Tolulope Sokoya +16 more
doaj +1 more source
The nutritional functions of dietary sphingomyelin and its applications in food
Frontiers in Nutrition, 2022 Sphingolipids are common structural components of cell membranes and are crucial for cell functions in physiological and pathophysiological conditions.
Fang Yang, Guoxun Chen
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Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation
Frontiers in Bioscience-Landmark, 2022 Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi +15 more
doaj +1 more source
Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2. [PDF]
Protein SciAbstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Das R, Mastrion HM, Vassar HB, Das A.
europepmc +2 more sources
Nature Communications, 2023 Although the human immunodeficiency virus type 1 lipid envelope has been reported to be enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the enrichment is not well understood.
Nario Tomishige +9 more
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Biochemistry and Biophysics Reports, 2016 Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
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Metabolism of sphingolipids by normal and atherosclerotic aorta of squirrel monkeys
Journal of Lipid Research, 1970 We studied the synthesis and hydrolysis of sphingomyelin by homogenates of aortic intima plus inner media from normal squirrel monkeys and from monkeys with nutritionally-induced atherosclerosis (6-10 mo on a semi-purified diet containing butter and ...
O.W. Portman, M. Alexander
doaj +1 more source
Foods, 2023 Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids.
Francisca S. Teixeira +7 more
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Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source