Results 21 to 30 of about 62,442 (260)

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

Frontiers in Microbiology, 2020
Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as well as periodic pandemics. A complete understanding of the virus pathogenesis and host factors involved in the viral lifecycle is crucial for developing novel ...
Amani Audi, Amani Audi, Nadia Soudani, Nadia Soudani, Nadia Soudani, Ghassan Dbaibo, Ghassan Dbaibo, Ghassan Dbaibo, Hassan Zaraket, Hassan Zaraket   +9 more
doaj   +1 more source

Keratinocytes Rapidly Readjust Ceramide–Sphingomyelin Homeostasis and Contain a Phosphatidylcholine–Sphingomyelin Transacylase [PDF]

, 2004
Ceramide as central second messenger of the apoptosis-related sphingomyelin signaling pathway is a potential target for the control of cancer. A complex metabolizing network defines cell type and stage-specific final ceramide concentrations.
Wittig, Burghardt, Wanner, Reinhard, Peiser, Matthias   +2 more
core   +1 more source

Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells

Lipids in Health and Disease, 2011
Background Studies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the development of atherosclerosis, whereas epidemiological studies have also shown that plasma sphingomyelin level is an independent ...
Li Yue, Dong Jibin, Ding Tingbo, Yan Nianlong, Wu Manping   +4 more
doaj   +1 more source

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

Journal of Lipid Research, 2005
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled ...
Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman   +5 more
doaj   +1 more source

Modeling SMS driven conversion of ceramide to sphingomyelin reveals the existence of a positive feedback mechanism [PDF]

, 2022
In questa tesi presentiamo un modello matematico minimo per la conversione di un ceramide in sfingomielina catalizzata dall'enzima sfingomielina sintasi 1 (SMS1) basato sulle leggi della cinetica chimica.
Thomaseth, Caterina
core  

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

Journal of Lipid Research, 1995
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj   +1 more source

N-cholesteryl sphingomyelin—A synthetic sphingolipid with unique membrane properties [PDF]

, 2011
A sphingomyelin chimera in which the amide-linked acyl chain was replaced with cholesterol carbamate was prepared and its properties examined. The sphingomyelin/cholesterol chimera (N-cholesterol-D-erythro-sphingomyelin) was able to form unilamellar ...
Slotte, J. Peter, Katsumura, Shigeo, Christian Sergelius, Yamaguchi, Shou, Yamamoto, Tetsuya, Shigeo Katsumura, Shou Yamaguchi, J. Peter Slotte, Sergelius, Christian, Tetsuya Yamamoto   +9 more
core   +1 more source

Morphological and functional status of liver at rats having toxic hepatites during injections of the liposomes loaded by sphingomyelin or ceramide

Бюллетень сибирской медицины, 2005
At inflammation process development caused by CCl4 morphological and functional research of 200 rats liver tissue was carried out. The liposomes loaded by the components of a sphingomyelin lipid cycle – sphingomyelin and ceramide were administed.
R. Z. Zainagetdinov, V. A. Zavarzin, I. L. Purlik, S. V. Novitsky, V. Yu. Serebrov   +4 more
doaj   +1 more source

Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice

Molecules, 2022
Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was ...
Yejin Ahn, Min Guk Kim, Kyungae Jo, Ki-Bae Hong, Hyung Joo Suh   +4 more
doaj   +1 more source

Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson’s Disease

Cells, 2022
The biomarkers of Parkinson’s disease (PD) remain to be investigated. This work aimed to identify blood biomarkers for PD using targeted metabolomics analysis.
Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen   +5 more
doaj   +1 more source