Results 21 to 30 of about 51,484 (237)

Sphingomyelin Lipidosis in a Cat [PDF]

Veterinary Pathology, 1987
A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times
H J, Baker, P A, Wood, D A, Wenger, S U, Walkley, K, Inui, T, Kudoh, M C, Rattazzi, B L, Riddle   +7 more
openaire   +2 more sources

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

Journal of Lipid Research, 1994
Macrophage acyl-CoA:cholesterol O-acyltransferase (ACAT), a key enzyme in atheroma foam cell formation, is stimulated by lipoproteins only after a “threshold” amount of cholesterol has accumulated in the cell.
A.K. Okwu, X.X. Xu, Y. Shiratori, I. Tabas   +3 more
doaj   +1 more source

Membrane properties of sphingomyelins [PDF]

FEBS Letters, 2002
Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
openaire   +2 more sources

Optimization of Giant Unilamellar Vesicle Electroformation for Phosphatidylcholine/Sphingomyelin/Cholesterol Ternary Mixtures

Membranes, 2022
Artificial vesicles are important tools in membrane research because they enable studying membrane properties in controlled conditions. Giant unilamellar vesicles (GUVs) are specially interesting due to their similarity in size to eukaryotic cells.
Zvonimir Boban, Ivan Mardešić, Witold Karol Subczynski, Dražan Jozić, Marija Raguz   +4 more
doaj   +1 more source

Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism

The EuroBiotech Journal, 2017
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Cataldi Samuela, Lazzarini Andrea, Codini Michela, Cascianelli Giacomo, Floridi Alessandro, Bartoccini Elisa, Ceccarini Maria Rachele, Ambesi-Impiombato Francesco Saverio, Beccari Tommaso, Curcio Francesco, Albi Elisabetta   +10 more
doaj   +1 more source

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

Frontiers in Microbiology, 2020
Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as well as periodic pandemics. A complete understanding of the virus pathogenesis and host factors involved in the viral lifecycle is crucial for developing novel ...
Amani Audi, Amani Audi, Nadia Soudani, Nadia Soudani, Nadia Soudani, Ghassan Dbaibo, Ghassan Dbaibo, Ghassan Dbaibo, Hassan Zaraket, Hassan Zaraket   +9 more
doaj   +1 more source

Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells

Lipids in Health and Disease, 2011
Background Studies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the development of atherosclerosis, whereas epidemiological studies have also shown that plasma sphingomyelin level is an independent ...
Li Yue, Dong Jibin, Ding Tingbo, Yan Nianlong, Wu Manping   +4 more
doaj   +1 more source

Morphological and functional status of liver at rats having toxic hepatites during injections of the liposomes loaded by sphingomyelin or ceramide

Бюллетень сибирской медицины, 2005
At inflammation process development caused by CCl4 morphological and functional research of 200 rats liver tissue was carried out. The liposomes loaded by the components of a sphingomyelin lipid cycle – sphingomyelin and ceramide were administed.
R. Z. Zainagetdinov, V. A. Zavarzin, I. L. Purlik, S. V. Novitsky, V. Yu. Serebrov   +4 more
doaj   +1 more source

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

Journal of Lipid Research, 2005
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled ...
Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman   +5 more
doaj   +1 more source

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

Journal of Lipid Research, 1995
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj   +1 more source