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Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions
Lancet, The, 2021The sphingosine 1-phosphate (S1P) signalling pathways have important and diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for various diseases due to their involvement in regulation of lymphocyte trafficking, brain and ...
Jeffrey A Cohen
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Sphingosine-1-phosphate: an enigmatic signalling lipid
Nature Reviews Molecular Cell Biology, 2003Sarah Spiegel
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Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022Sphingosine 1-phosphate receptor (S1PR), as a kind of G protein-coupled receptor, has five subtypes, including S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. Sphingosine 1-phosphate receptor (S1P) and S1PR regulate the trafficking of neutrophils and some cells ...
Hongyu Chen +7 more
semanticscholar +1 more source
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
Science, 2019 Mediating systemic health Sphingosine 1-phosphate (S1P) is an important circulating lipid mediator that is derived from the metabolism of cell membranes.
Andreane Cartier, Timothy T Hla
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Sphingosine 1-phosphate receptors
Prostaglandins & Other Lipid Mediators, 2001Sphingosine-1-phosphate (SPP) is a bioactive lipid produced from the metabolism of sphingomyelin. It is an important constituent of serum and regulates cell growth, survival, migration, differentiation and gene expression. Its mode of action has been enigmatic; however, recent findings have shown that a family of G-protein-coupled receptors (GPCR) of ...
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Sphingosine-1-Phosphate Phosphatases
Prostaglandins & Other Lipid Mediators, 2001Sphingosine-1-phosphate is a potent proliferative, survival, and morphogenetic factor, acting as an extracellular ligand for the EDG family of G-protein-coupled receptors and possibly intracellularly through as yet, unidentified targets. It is produced within most, if not all cells by phosphorylation of sphingosine, and is an abundant serum lipid that ...
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Sphingosine 1-Phosphate Receptor Signaling
Annual Review of Biochemistry, 2009The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein–coupled receptors to generate multiple downstream signals.
Hugh, Rosen +3 more
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Pharmacology and Therapeutics, 2019
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinase 1
O. Sukocheva +11 more
semanticscholar +1 more source
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinase 1
O. Sukocheva +11 more
semanticscholar +1 more source
Modulation of sphingosine-1-phosphate in ulcerative colitis
Expert Opinion on Biological Therapy, 2020Introduction: Sphingosine-1-phosphate (S1P) is a membrane-derived lysophospholipid signaling molecule implicated in various physiological and pathological processes, such as regulation of the immune, cardiovascular, pulmonary, and nervous systems and ...
M. Argollo +6 more
semanticscholar +1 more source
Pharmacology and Therapeutics, 2019
Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine‐1‐phosphate (S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell proliferation and induce cell apoptosis while S1P has the opposite effect ...
Xiang-jin Zheng +8 more
semanticscholar +1 more source
Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine‐1‐phosphate (S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell proliferation and induce cell apoptosis while S1P has the opposite effect ...
Xiang-jin Zheng +8 more
semanticscholar +1 more source