Results 271 to 280 of about 327,382 (312)

Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis.

Life Science, 2020
OBJECTIVE Rheumatoid arthritis (RA) is a common inflammatory autoimmune disease characterized by the formation of joint synovitis and pannus. Sphingosine 1-phosphate (S1P) is an important mediator related to angiogenesis, inflammation and autoimmunity ...
Ming-Hui Sun, Ran Deng, Yan Wang, Hong Wu, Zhengrong Zhang, Yan-Hong Bu, Heng Zhang   +6 more
semanticscholar   +1 more source

Sphingosine-1-phosphate receptor 3 signaling

Clinica Chimica Acta, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5.
Qian Li, Yi Li, Cai Lei, Ying Tan, Guanghui Yi   +4 more
openaire   +2 more sources

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

Nature, 2017
Thiet M Vu, Juat Chin Foo, Federico T Torta   +2 more
exaly   +2 more sources

The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators

Neurology, 2011
Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven, Veronique, Miron, Jerold, Chun   +2 more
openaire   +2 more sources

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
openaire   +2 more sources

Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease

Nature reviews: Gastroenterology & hepatology, 2022
B. Verstockt, S. Vetrano, A. Salas, S. Nayeri, M. Duijvestein, N. Vande Casteele, Silvio Geert Lars William A. Brian G. Vipul Christopher D Danese D’Haens Eckmann Faubion Feagan Jairath Ma M, S. Danese, G. D'Haens, L. Eckmann, W. Faubion, B. Feagan, V. Jairath, Christopher Ma, D. McGovern, J. Panés, W. Sandborn, M. Silverberg, S. Vermeire   +18 more
semanticscholar   +1 more source

Sphingosine 1-Phosphate Breakdown in Platelets

Journal of Biochemistry, 2004
We examined the formation of sphingolipid mediators in platelets, which abundantly store, and release extracellularly, sphingosine 1-phosphate (Sph-1-P). Challenging [(3)H]Sph-labeled platelet suspensions with thrombin or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in a decrease in Sph-1-P formation and an increase in sphingosine (Sph ...
Yutaka, Yatomi, Soichiro, Yamamura, Nobuo, Hisano, Kazuhiko, Nakahara, Yasuyuki, Igarashi, Yukio, Ozaki   +5 more
openaire   +2 more sources

Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis

CNS Drugs, 2021
Reshmi Roy, Alaa A. Alotaibi, M. Freedman   +2 more
semanticscholar   +1 more source

Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

Nature Chemical Biology, 2021
Zhenmei Xu, T. Ikuta, Kouki Kawakami, Ryoji Kise, Yu Qian, R. Xia, Ming-xia Sun, Anqi Zhang, Chuanyong Guo, Xue-Hui Cai, Zhiwei Huang, A. Inoue, Yuanzheng He   +12 more
semanticscholar   +1 more source

Sphingosine 1-phosphate signalling in cancer

Biochemical Society Transactions, 2012
There is an increasing body of evidence demonstrating a critical role for the bioactive lipid S1P (sphingosine 1-phosphate) in cancer. S1P is synthesized and metabolized by a number of enzymes, including sphingosine kinase, S1P lyase and S1P phosphatases. S1P binds to cell-surface G-protein-coupled receptors (S1P1–S1P5) to elicit cell responses and can
Nigel J, Pyne, Francesca, Tonelli, Keng Gat, Lim, Jaclyn S, Long, Joanne, Edwards, Susan, Pyne   +5 more
openaire   +2 more sources