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Sphingosine 1-phosphate: synthesis and release
Prostaglandins & Other Lipid Mediators, 2001Sphingosine 1-phosphate (Sph-1-P) is a bioactive sphingolipid, acting both as an intracellular second messenger and extracellular mediator, in mammalian cells. In cell types where Sph-1-P acts as an intracellular messenger, stimulation-dependent synthesis of Sph-1-P, possibly resulting from sphingosine (Sph) kinase activation, is essential.
Y, Yatomi +3 more
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2006
Sphingosine-1-phosphate lyase is responsible for the ultimate step in sphingolipid degradation. Sphingosine-1-phosphate and other phosphorylated long chain bases generated through the actions of sphingosine kinase may be dephosphorylated by lipid phosphatases or cleaved at the C2–3 carbon-carbon bond by the pyridoxal 5’-phosphate-dependent enzyme ...
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Sphingosine-1-phosphate lyase is responsible for the ultimate step in sphingolipid degradation. Sphingosine-1-phosphate and other phosphorylated long chain bases generated through the actions of sphingosine kinase may be dephosphorylated by lipid phosphatases or cleaved at the C2–3 carbon-carbon bond by the pyridoxal 5’-phosphate-dependent enzyme ...
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[Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface.
Xin-pin, Zhuang, Qing, Zhu
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Sphingosine 1‐Phosphate Signalling
2019It is an invited review about the biological role and the mechanism of action of sphingosine 1-phosphate, eary powerful bioactive ...
BERNACCHIONI CATERINA +3 more
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Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
Science, 2002Suzanne M. Mandala +15 more
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