Acta Crystallographica Section D, Volume 82, Issue 4, Page 383-396, April 2026.This study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Dayong Zhou +3 more
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Neuroprotective crosstalk from vitamin B12 and sphingolipid signaling pathways in therapy for multiple sclerosis. [PDF]
Int ImmunolKihara Y, Chun J.
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Aging Cell, Volume 25, Issue 4, April 2026.Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier +10 more
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Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load. [PDF]
PLoS Negl Trop DisMadan E +7 more
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The high‐density lipoprotein lipidome in metabolic syndrome: A systematic review
European Journal of Clinical Investigation, Volume 56, Issue 4, April 2026.This graphical abstract illustrates the high‐density lipoprotein (HDL) lipidome remodelling in metabolic syndrome (MetS) when compared to control subjects. Alterations occur in both HDL surface and core lipids. On the one hand, surface lipids such as phosphatidylinositol and triacylglycerides are higher in MetS, while free cholesterol, sphingomyelin ...
Elena Grao‐Cruces +6 more
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Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma. [PDF]
Int J Biol SciJang HR +8 more
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Linear ion-trap MSn with high-resolution MS reveals structural diversity of 1-O-acylceramide family in mouse epidermis [PDF]
, 2017 Hsu, Fong-Fu +3 more
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EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
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Sphingosine-1-Phosphate Regulation to Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach. [PDF]
Saudi Med JChathoth S.
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HIV Medicine, Volume 27, Issue 4, Page 498-512, April 2026.Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre +2 more
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