Results 151 to 160 of about 84,296 (269)

Therapeutic Decisions in Inflammatory Bowel Disease: ChatGPT‐4.0 Compared to Medical Expertise

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Introduction With the increasing prevalence of inflammatory bowel disease (IBD) and its complex management, evaluating innovative approaches became essential. Large language models (LLM), such as ChatGPT‐4.0, have remarkably advanced, yet their application in IBD management remains unexplored.
Helena Loncour, Jennifer Aoun, Alice Hoyois, Vinciane Muls   +3 more
wiley   +1 more source

Advances in Crohn's Disease: A Comprehensive Review of Pathophysiology, Diagnosis, and Emerging Therapeutics

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the bowel with a rising global incidence. Its complex etiology involves genetic susceptibility, environmental factors, and alterations in the gut microbiota, leading to dysregulated immune responses.
Yoon‐Kyo An, Robert Gilmore, Graham Radford‐Smith, Jakob Begun   +3 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis

MedComm, Volume 7, Issue 4, April 2026.
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu, Chunxiao Cheng, Xiong‐Fei Pan, Wei Shao, Dan Zhou, Yimin Zhu   +5 more
wiley   +1 more source

Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood

Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.
Metabolic and nutritional stressors are a growing global health concern. This review discusses how obesity, lipids, and lipid derivatives influence lung development, homeostasis, and chronic lung disease progression, highlighting roles of alveolar surfactant and sphingolipids.
Jaco Selle, Natascha Mierswa, Leon Saschin, Jana Niehues, Jörg Dötsch, Eva Nüsken, Kai‐Dietrich Nüsken, Julia Schipke, Miguel A. Alejandre Alcazar   +8 more
wiley   +1 more source

Rhinovirus infection promotes suppression of sphingosine and enhanced bacterial infection in cystic fibrosis airways. [PDF]

J Biol Chem
Wilson GC, Keitsch S, Wilker B, Soddemann M, Kamler M, Gulbins E.   +5 more
europepmc   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau, Nicoletta Luxi, Fabio Riefolo, Martín Solorzano, Irene Pazos, Elena Ballarín, Lise Skovgaard Svingel, Lorenzo Chiusaroli, Elisa Martín‐Merino, Elisa Barbieri, María Lopez‐Lasanta, Sima Mohammadi, Denis Rotta, Alexandra Pacurariu, Catherine Cohet, Miriam Sturkenboom, Carlos E. Durán, on behalf of the SAFETY‐VAC study consortium, Carlos E. Durán, Miriam Sturkenboom, Judit Riera‐Arnau, Nicoletta Luxi, Olaf Klungel, Patrick Souverein, Sima Mohammadi, Fabio Riefolo, Irene Pazos, Rosa Gini, Davide Messina, Giuseppe Roberto, Carlo Giaquinto, Elisa Barbieri, Luca Stona, Felipe Villalobos, Martín Solorzano, Carlo Alberto Bissacco, Antonio Gimeno, Beatriz Poblador, Mercedes Aza, Aida Moreno, Alejandro Santos, Vera Ehrenstein, Lise Skovgaard Svingel, Benjamin Randeris Johannesen, Cécile Droz‐Perroteau, Laure Carcaillon‐Bentata, Anna‐Mija Tolppanen, Sirpa Hartikainen, Thuan Vo, Anne Paakinaho, Blair Rajamaki, Hedvig Nordeng, Saeed Hayati, Mahmoud Zidan, Juan José Carreras Martínez, Arantxa Urchueguía Fornes, Elisa Correcher Martínez, Javier Díez‐Domingo, Mar Martin, Patricia Garcia‐Poza, Airam de Burgos, Belén Castillo‐Cano, Elisa Martín‐Merino   +62 more
wiley   +1 more source

The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues. [PDF]

J Endocr Soc
Mbadhi MN, Fujiwara H, Gill R, Mitchum KT, Lin ZC, Raghuraman N, Frolova AI.   +6 more
europepmc   +1 more source

Targeting Sphingosine‐1‐Phosphate Signaling Attenuates Doxorubicin‐Aggravated Bone Loss in Obese Breast Cancer Mice

Smart Medicine, Volume 5, Issue 2, April 2026.
During obese breast cancer‐bearing mice undergoing chemotherapy, DOX increases the concentration of S1P produced by breast cancer cells, which induces osteoclastogenesis through the activation of the S1PR1/p‐STAT3/NFATc‐1 pathway, thereby exacerbating bone loss in the breast cancer‐bearing mice with high‐fat dietary.
Yu Zhang, Hao Shen, Junjie Niu, Yingkang Huang, Can Zhu, Yi Wang, Yida Chen, Xinyi Cheng, Huilin Yang, Xianrong Zhang, Hao Chen, Hongbo Zhang, Qin Shi   +12 more
wiley   +1 more source

PET study of sphingosine-1-phosphate receptor 1 expression in response to vascular inflammation in a rat model of carotid injury [PDF]

, 2017
Abendschein, Dana R, Baum, Pamela, Han, Junbin, Jin, Hongjun, Liu, Hui, Tu, Zhude, Yue, Xuyi   +6 more
core   +2 more sources