Results 131 to 140 of about 57,421 (279)

Sphingosine Prevents Rhinoviral Infections

Rhinoviral infections cause approximately 50% of upper respiratory tract infections and novel treatment options are urgently required. We tested the effects of 10 μM to 20 μM sphingosine on the infection of cultured and freshly isolated human cells
Michael J. Edwards, Gregory C. Wilson, Karl S. Lang, Matthias Soddemann, Judith Lang, Erich Gulbins   +5 more
core   +1 more source

Sphingosine-induced c-jun expression: differences between sphingosine- and C2-ceramide-mediated signaling pathways

, 2002
Sphingolipids such as ceramide and sphingosine are putative intracellular signal mediators in cell differentiation, growth inhibition and apoptosis. Previously, we reported that C2-ceramide induced c-jun expression in apoptosis of human leukemia HL-60 ...
Domae, Naochika, Okazaki, Toshiro, Toshiro Okazaki, Sawai, Hirofumi, Naochika Domae, Hirofumi Sawai   +5 more
core   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Generierung von Sphingosin-1-Phosphat durch apoptotische Zellen und dessen Einfluss auf die Polarisierung von Makrophagen während der Tumorentwicklung

, 2008
The removal of apoptotic cells (AC) can be regarded as an integral component of the program to terminate inflammation. Clearance of AC by professional phagocytes such as macrophages induces an anti-inflammatory phenotype in the latter ones.
Weigert, Andreas
core  

Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator

, 2011
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems.
Bianca Hegen, van Echten-Deckert, Gerhild, Huwiler, Andrea, Dagmar Meyer zu Heringdorf, Sandra Labocha, Michael ter Braak, Heringdorf, Dagmar Meyer Zu, Gerhild van Echten-Deckert, Labocha, Sandra, Ferreirós, Nerea, Meyer Zu Heringdorf, Dagmar, Ter Braak, Michael, Josef Pfeilschifter, Pfeilschifter, Josef, Nerea Ferreirós, Ralf Frederik Claas, Hegen, Bianca, Andrea Huwiler, Claas, Ralf Frederik   +18 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Macrophage polarization by apoptotic cancer cells - a RNAi high-throughput screen and validation of interleukin 10 regulation

, 2012
Tumor-associated macrophages (TAM) are a major supportive component within neoplasms and by their plasticity promote all phases of tumor development. Mechanisms of macrophage (M Phi) attraction and differentiation to a tumor-promoting phenotype, defined ...
Ley, Stephanie
core  

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

The effects of exogenous sphingosine on neuro2a cells are strictly related to the overall capacity of cells to metabolize sphingosine

, 1998
Neuro2a cells were exposed to different doses (1-40 nmol/106 cells) of [C3-3H] sphingosine and the relationship between metabolism and biological effects of sphingosine was investigated. Sphingosine appeared to be rapidly taken up and metabolized.
P. Viani, G. Tettamanti, L. Riboni, A. Prinetti, R. Bassi   +4 more
core   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, EarlyView.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source