Results 131 to 140 of about 84,296 (269)

Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. [PDF]

, 2019
Age and Alzheimer's disease (AD) share some common features such as cognitive impairments, memory loss, metabolic disturbances, bioenergetic deficits, and inflammation.
Brewer, Gregory J, Dong, Yue
core  

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

Studies on Sphingosines. 6. C16- and C17-Sphingosines, hitherto Unknown Sphingosines. [PDF]

Acta Chemica Scandinavica, 1964
Karl-Anders Karlsson, O. Hassel, Chr. Römming, D. R. Sparrow   +3 more
openaire   +1 more source

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

Glia, Volume 74, Issue 5, May 2026.
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel   +4 more
wiley   +1 more source

Pouch Surgery for Ulcerative Colitis: Navigating Complexity in the Modern Era

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) remains the preferred surgical treatment for patients with ulcerative colitis (UC) who require surgery but wish to avoid a permanent ileostomy. Since its introduction in 1978, IPAA has undergone continuous refinement in response to advances in both medical therapy and ...
Gabriele Bislenghi, Caroline Nordenvall, Anthony de Buck van Overstraeten, Peter Kienle, Alaa El‐Hussuna   +4 more
wiley   +1 more source

Sphingosylphosphorylcholine is a substrate for the Pseudomonas aeruginosa phospholipase C/sphingomyelinase, PlcH

Microbiology Spectrum
Sphingolipids are critical to eukaryotic cell membrane structure and function and play important roles in a variety of host processes that impact infection.
Pauline DiGianivittorio, Kristin Schutz, Lauren A. Hinkel, Matthew J. Wargo   +3 more
doaj   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Receptor 3 Confers Tumor Metastasis in Lung Cancer Resistant to Third‐Generation EGFR Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
• S1PR3 drives metastasis in EGFR TKI‐resistant lung cancer by activating RAC1‐PAK1 signaling and promoting EMT. • FGFR1‐STAT4 axis upregulates S1PR3, enabling metastatic escape in resistant tumors. • Targeting S1PR3 or FGFR1 suppresses metastasis, offering a therapeutic strategy for EGFR TKI‐resistant lung cancer.
Mengzhen Lai, Jiaying Chen, Ye Qin, Hui Zhang, Zilu Pan, Tao Zhang, Linjiang Tong, Haotian Tang, Gang Bai, Qiupei Liu, Yan Li, Fang Feng, Peiran Song, Yingqiang Liu, Yi Chen, Yan Fang, Bencan Tang, Meiyu Geng, Ker Yu, Hao Chen, Jian Ding, Hua Xie   +21 more
wiley   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, Volume 36, Issue 3, May 2026.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source